GlucoCEST magnetic resonance imaging in  vivo may be diagnostic of acute renal allograft rejection

Acute cellular renal allograft rejection (AR) frequently occurs  after kidney transplantations. It is a sterile T-cell mediated inflammation leading to increased local glucose metabolism. Here we demonstrate in an allogeneic model of Brown Norway rat kidneys transplanted into uninephrectomized Lewis rats the successful implementation of the recently developed glucose chemical exchange saturation transfer (glucoCEST) magnetic resonance imaging. This technique is a novel method to assess and differentiate AR.

Source: Kidney International - July 12, 2017 Category: Urology & Nephrology Authors: Dominik Kentrup, Philipp Bovenkamp, Annika Busch, Katharina Schuette-Nuetgen, Helga Pawelski, Hermann Pavenst ädt, Eberhard Schlatter, Karl-Heinz Herrmann, Jürgen R. Reichenbach, Bettina Löffler, Barbara Heitplatz, Veerle Van Marck, Nirbhay N. Yadav, G Tags: Technical Notes Source Type: research