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Medical News Today: Peroneal tendonitis: Causes, treatment, and recovery

Peroneal tendonitis affects the tendons, and can make movement difficult and painful. Learn about the causes, treatments, and outlook for this condition.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

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Molecules, Vol. 23, Pages 988: Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund’s Adjuvant-Induced Mono-Arthritis Molecules doi: 10.3390/molecules23050988 Authors: João Francisco Silva Rodrigues Cristiane Silva e Silva Thayanne França Muniz Alana Fernanda de Aquino Larissa Neuza da Silva Nina Nagila Caroline Fialho Sousa Luis Claudio Nascimento da Silva Breno Glaessner Gomes Fernandes de Souza Tatiana Aranha da Penha Ana Lúcia Abreu-Silva Joicy Cortez de Sá Elizabeth Soares Fernandes Marcos Augusto Grigolin Grisotto Rheumatoid a...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
In this study, an articular cavity microdialysis sampling system for adjuvant arthritic (AA) rats was established to study the effect of GE on the release of prostaglandin E2 (PGE2) in AA rats induced by Freund’s complete adjuvant (FCA). An UHPLC-MS/MS method was developed to determine the concentrations of GE and PGE2 in the dialysate. Through the determination of drug concentrations and PGE2 efficacy levels in the dialysate, the developed methods were successfully applied to set up concentration–time and effect–time profiles followed by PK–PD modeling of GE’s effect on decreasing PGE2 releas...
Source: Molecules - Category: Chemistry Authors: Tags: Essay Source Type: research
(Reuters) - An arthritis drug developed by Eli Lilly&Co and Incyte Corp should not be approved at a 4-milligram dose, advisers to the U.S. FDA voted on Monday, in a setback to the drugmakers that were counting on the treatment as a future blockbuster.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
(Reuters) - A rheumatoid arthritis drug developed by Eli Lilly and Incyte Corp should not be approved at a higher dose, a U.S. Food and Drug Administration advisory committee voted on Monday, while backing the approval of a lower dose.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
This study identified the factors that have an impact on RA drug treatment expenditure. Also, we showed that methods that enable extracting demographic and expenditure data of administrative information systems may represent important tools in the construction of economic studies to subsidize economic health evaluations, especially from the standpoint of the managers.
Source: Ciencia e Saude Coletiva - Category: Occupational Health Source Type: research
Ichor Therapeutics is the most mature of the US-based companies that have emerged from the SENS rejuvenation research community in recent years. You might recall a number of interviews back in the Fight Aging! Archives with founder and CEO Kelsey Moody. He has his own take on how our community should proceed from laboratory to clinic: he is very much in favor of demonstrating (a) that the formal regulatory path offered by the FDA can work for the treatment of aging, and (b) that - given the right strategic approach - rejuvenation therapies can attract the attention, collaboration, and backing of Big Pharma entities in the ...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
AbstractThe goals of this study were to determine if secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis (RA) compared to control subjects and to examine the relationships of S-SMase activity with functional status, quality of life, and RA disease activity measurements. We collected data on 33 patients who were diagnosed with RA and 17 non-RA controls who were comparable in terms of age, sex, and race. Demographic, clinical data and self-reported measures of fatigue, pain, and physical function were obtained directly from patients and controls. RA patients also completed quantita...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractThe study aims to analyse the clinical and immunological manifestations of paediatric antiphospholipid syndrome (APS) in patients, based on the 2006 revised classification criteria of definite APS. Fifty-eight paediatric patients with APS were enrolled and analysed retrospectively. A total of 37 female and 21 male patients with a mean age of 14  ± 3 years at disease onset were included. Fourteen (24%) cases were primary APS, and 40 (69%) cases were secondary to systemic lupus erythaematosus (SLE). Anti-nuclear antibody (ANA) positivity and hypocomplementemia were more common in secondary APS t...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractAssessment of intracranial vessels includes transcranial Doppler (TCD). TCD performance requires intact temporal acoustic windows (TAW). Failure of TAW (TAWF) is present in 8 –20% of people. There have been no reports on TAWF in rheumatoid arthritis (RA). Altogether, 62 female RA patients were included. Among them, 20 were MTX-treated and biologic-free, 20 received infliximab, and 22 tocilizumab. The controls included 60 non-RA women. TAWF, temporal bone thickness, and texture were determined by ultrasound and CT. BMD and T-scores of multiple bones were determined by DEXA. Several bone biomarkers were assesse...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Roxanne Cooksey, a research fellow at Swansea University, explains the clearest ever evidence of a strong link between inflammatory conditions of the skin and bones, and heart woes.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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