The Use of Endobronchial Ultrasound–guided Transbronchial Needle Aspiration Cytology Specimens for Programmed Death Ligand 1 Immunohistochemistry Testing in Non–Small Cell Lung Cancer

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Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Editorials Source Type: research

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ConclusionThe combination of elastography and sonographic findings showed good sensitivity and a high negative predictive value, which may facilitate selecting the most suspicious lymph nodes for biopsy.Key pointsSignificant findings of the study.The combination of endobronchial elastography and sonography resulted in a higher diagnostic yield than either modality alone for predicting benign and malignant lymph nodes in patients with lung cancer.What this study adds.The combination of endobronchial elastography and sonography will help clinicians identify the most suspicious lymph nodes for puncturing during EBUS ‐TBNA, ...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Mediastinal restaging after induction treatment is still a difficult and controversial issue. We aimed to investigate the diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for restaging the mediastinum after induction treatment in patients with lung cancer.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
In this case series, we describe three cases of lung malignancy diagnosed using three distinct applications of endobronchial ultrasound ‐guided transbronchial needle aspiration (EBUS‐TBNA) and endoscopic ultrasound with bronchoscope‐guided fine‐needle aspiration (EUS‐B‐FNA). Both procedures can be performed in a single session and by a single operator; this translates into an overall reduction in the healthcare cost. Whe n EBUS‐TBNA and EUS‐B‐FNA are combined, the technique allows for the augmentation of diagnostic potentials and increased precision in staging procedures. Endobronchial ultrasound (EBUS) i...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Series Source Type: research
Conclusions: Our study indicates that solid nodules have the highest risk of malignancy. Furthermore, the cytological evaluation of subsolid and partially calcified nodules is crucial for the accurate diagnosis and appropriate clinical management of lung nodule patients.
Source: CytoJournal - Category: Pathology Authors: Source Type: research
We describe two patients with advanced non ‐small‐cell lung cancer (NSCLC), including one in whom the definitive diagnosis of pulmonary pleomorphic carcinoma (PPC) was made by histopathology of the resected tumour and another in whom the diagnosis of “favor adenocarcinoma containing sarcomatoid components” was made by tissue biopsy. Both were resistant to first line platinum‐based chemotherapy, but responded dramatically to second line nivolumab therapy. We present two cases of pulmonary pleomorphic carcinoma (PPC) treated with Nivolumab. A 57 ‐year‐old man presented with a 3.5‐cm mass in the left l...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
There is increasing awareness of the role of the tumor-draining lymph node (TDLN) as an early site of both immune activation and evasion by non-small cell lung cancers (NSCLC) 1,2. While there have been tremendous advances in our understanding of the dynamic process of immunoediting in the tumor microenvironment and its prognostic significance, less is known about changes in effector and regulatory mechanisms at the level of the TDLN 3 –7. There are several features of both the tumor and TDLN that attenuate effective immune activation, including defects in antigen presentation, induction of anergy in effector T cells...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Authors: Sakairi Y, Nakajima T, Yoshino I Abstract Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a low-invasive modality that shows excellent sensitivity, specificity, and accuracy in the diagnosis of nodal metastasis of lung cancer. Thus, EBUS-TBNA has become the first choice for nodal staging of non-small cell lung cancer and an alternative to mediastinoscopy, which had long been the gold standard. EBUS-TBNA can be utilized not only for initial cancer staging but also for staging after treatment or for diagnostic purposes, including molecular diagnostics. Adequate s...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
This study was performed in order to define the prevalence of mediastinal LN metastases discovered on combined endosonography by endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS) fine needle aspiration in patients with a radiologically normal mediastinum. This study consists of a retrospective, single-institution, tertiary care referral center review of a prospectively maintained database.
Source: Seminars in Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: THORACIC – Original Submission Source Type: research
Conclusion: Preoperative systematic staging by EBUS-TBNA of early lung cancer can reduce postoperative upstaging. Sensitivity for detection of radiologically occult mediastinal metastases seems lower than selective sampling of pathologic lymph nodes. Verification of negative results by mediastinoscopy in selected cases remains of value.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Conclusion: EBUS-TBNA using either capillary sampling or complete stylet removal are effective and has a high proportion of satisfactory results for ancillary testing.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Brief Report Source Type: research
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