Equashield seeks to automate hazardous drug handling: a Drug Delivery Business News podcast

Equashield’s Jason Dutcher chats with Drug Delivery Business Newseditor Sarah Faulkner about the company’s closed system transfer device and its latest move to automate hazardous drug compounding.  Healthcare workers are often tasked with handling hazardous drugs, which give off harmful vapors. Exposure to these drugs has been linked to severe health risks, including infertility, miscarriage and cancer. To guard workers against exposure to toxic compounds, Equashield has developed a streamlined closed system transfer device for the handling of hazardous drugs. Get the full story at our sister site, Drug Delivery Business News. The post Equashield seeks to automate hazardous drug handling: a Drug Delivery Business News podcast appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Drug-Device Combinations Oncology Pharmaceuticals Robotics equashield Source Type: news

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Abstract A balanced Robertsonian translocation results from fusion of two acrocentric chromosomes. Carriers are phenotypically normal, and are often diagnosed because of recurrent miscarriages, infertility or aneuploid offspring. Mortality and site-specific cancer risks in carriers have not been prospectively investigated. We followed 1987 carriers diagnosed in Great Britain for deaths and cancer risk, over an average of 24.1 years. Standardised mortality (SMR) and incidence (SIR) ratios were calculated comparing the number of observed events against population rates. Overall mortality was raised for carriers diagnosed aged
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
Constitutional (germline) chromosomal rearrangements, including translocations and inversions, are well recognized for their potential to impact fertility and miscarriage risk [1,2]. Conventional chromosome studies are routinely performed on adult patients with histories of infertility or recurrent miscarriages, and it is under these circumstances when constitutional rearrangements are often revealed [1,2]. However, in this context, carriers of constitutional rearrangements are often phenotypically and cognitively normal (assuming the rearrangements are truly balanced and genes of clinical significance are intact) and thes...
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research
By Michelle Catenacci, M.DCHICAGO, Jun 18 2018 (IPS)Fertility health is an incredibly personal – and often vulnerable – topic. Fertility, infertility, and fertility preservation have gained increased public interest over the past few years. Infertility is formally defined as the inability to achieve pregnancy after one year of unprotected intercourse. The Centers for Disease Control and Prevention (CDC) reports that approximately 12% of women aged 15 to 44 in the United States have difficulty getting pregnant or carrying a pregnancy to term. Even though a significant proportion of the population suffers from th...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Education Featured Gender Global Headlines Health Population Poverty & SDGs TerraViva United Nations Source Type: news
A new study in the journal Nature Cell Biology has uncovered information about a key stage that human embryonic cells must pass through just before an embryo implants. The research, led by UCLA biologist Amander Clark, could help explain certain causes of infertility and spontaneous miscarriage.Infertility affects around 10 percent of the U.S. population, and roughly 15 to 20 percent of all pregnancies in the U.S. end in miscarriage. In many cases, the causes of infertility and miscarriage are unknown.A team led by Clark, a UCLA professor of molecular cell and developmental biology and member of the  Eli and Edythe Br...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
We present a case series of 2 sisters in their 20s who presented with isolated uterine leiomyomas and were found to carry a novel mutation for the fumarate hydratase gene. One patient was referred for treatment of infertility and recurrent miscarriages and the other was referred for acute symptomatic anemia due to myomas. Prompt diagnosis of hereditary leiomyomatosis renal cell cancer was made due to a high index of clinical suspicion based on early onset disease and familial clustering as well as characteristic pathologic findings on uterine leiomyoma surgical specimen. Timely diagnosis not only allowed for genetic counse...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: Pathology of the Corpus: Case Report Source Type: research
*This blog was first published at DNA Science Blog at Public Library of Science* The spindle apparatus is among the most elegant structures in a cell, quickly self-assembling from microtubules and grabbing and aligning chromosomes so that equal sets separate into the two daughter cells that result from a division. But can spindles in cells held at the brink of division in the suspended animation of the deep freeze at a fertility clinic survive being ripped from their slumber off-protocol, as happened the weekend of March 4 at the Pacific Fertility Clinic in San Francisco and University Hospitals Fe...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care Fertility syndicated Source Type: blogs
AbstractAdult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically. By contrast, radiation is detrimental to both the ovaries and the uterus, thereby causing a gr...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Review, Gynecologic Oncology Source Type: research
Conclusions Except for the risk of premature ovarian failure, a rare adverse effect of combined treatments, both single-agent and multiagent chemotherapy can be safely administered to patients with a desire for childbearing. High-risk patients have worse reproductive outcomes because they undergo hysterectomy more frequently than low-risk patients.
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Gestational Cancer Source Type: research
ConclusionsAMH should replace FSH in the evaluation of gonadal reserve in pre-menopausal thyroid cancer women. At present, age is the only predictor of AMH levels. About one out of two women with a history of thyroid cancer suffers from menstrual dysregulation, but infertility must be considered a low risk.
Source: Endocrine - Category: Endocrinology Source Type: research
Abstract Adult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically. By contrast, radiation is detrimental to both the ovaries and the uterus, thereby ca...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
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