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Three-year Safety of Radium-223 Dichloride in Patients with Castration-resistant Prostate Cancer and Symptomatic Bone Metastases from Phase 3 Randomized Alpharadin in Symptomatic Prostate Cancer Trial

Conclusions Final long-term safety ALSYMPCA analysis shows that radium-223 remained well tolerated, with low myelosuppression incidence and no new safety concerns. Patient summary Updated Alpharadin in Symptomatic Prostate Cancer (ALSYMPCA) trial findings show that radium-223 remained well tolerated during treatment and up to 3 yr after each patient's first injection. Three-year safety follow-up of Alpharadin in Symptomatic Prostate Cancer (ALSYMPCA) trial patients with castration-resistant prostate cancer and symptomatic bone metastases revealed a continued low incidence of myelosuppression, minimal nonhematologic adverse events, and secondary malignancies (none related to treatment) in four radium-223 patients and three placebo patients.
Source: European Urology - Category: Urology & Nephrology Source Type: research

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STOMACH cancer symptoms include a poor appetite, weight loss, and nausea. Treatment can include operations as well as changes to what you eat. Adapting your diet to include more of these foods could help to treat the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This report warns that reluctance to talk honestly about death is preventing people with cancer from dying'well'. It calls for Governments across the UK to honour their commitments to ensuring Advance Care Planning is used as an important part of a person-centred health service, so that people approaching the end of their lives receive the best care possible and their wishes for death and dying are fulfilled
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
AN artificial intelligence revolution to prevent 22,000 cancer deaths by 2033 was being unveiled today. Theresa May is challenging the NHS to transform healthcare.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The prognostic value of high sensitivity C-reactive protein in a multi-ethnic population after>10 years of follow-up: The Multi-Ethnic Study of Atherosclerosis (MESA). Int J Cardiol. 2018 Aug 01;264:158-164 Authors: Cainzos-Achirica M, Miedema MD, McEvoy JW, Cushman M, Dardari Z, Greenland P, Nasir K, Budoff MJ, Al-Mallah MH, Yeboah J, Blumenthal RS, Comin-Colet J, Blaha MJ Abstract BACKGROUND: The prognostic value of hsCRP in contemporary multi-ethnic populations is unclear, particularly in statin users. The aim of this study was to characterize the prognostic utility of hsCRP for atheroscleroti...
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Int J Cardiol Source Type: research
Abstract The molecular pathogenesis and classification of colorectal carcinoma are based on the traditional adenomaecarcinoma sequence, serrated polyp pathway, and microsatellite instability (MSI). The genetic basis for hereditary nonpolyposis colorectal cancer is the detection of mutations in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes. Genetic testing for Lynch syndrome includes MSI testing, methylator phenotype testing, BRAF mutation testing, and molecular testing for germline mutations in MMR genes. Molecular makers with predictive and prognostic implications include quantitative multigene reverse transcriptas...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Lab Med Source Type: research
Abstract MicroRNAs (miRNAs) are poised to provide diagnostic, prognostic, and therapeutic targets for several diseases including malignancies for precision medicine applications. The miRNAs have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and fine-needle aspirate specimens. The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that may provid...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Lab Med Source Type: research
Authors: Stahlschmidt A, Novelo B, Alexi Freitas L, Cavalcante Passos S, Dussián-Sarria JA, Félix EA, Wajnberg Gamermann P, Caumo W, Cadore Stefani LP Abstract INTRODUCTION: Morbidity and mortality associated with urgent or emergency surgeries are high compared to elective procedures. Perioperative risk scores identify the non-elective character as an independent factor of complications and death. The present study aims to characterize the population undergoing non-elective surgeries at the Hospital de Clínicas de Porto Alegre and identify the clinical and surgical factors associated with death...
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
CONCLUSIONS: Ring-shaped thread counter traction makes the most difficult duodenal ESD safer and easier without complications. PMID: 29764299 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
A 69-year-old man was referred to our department because of renal masses of the left kidney. The patient was diagnosed with a bladder carcinoma 10 months before in the context of macroscopic hematuria. The cancer had a partial squamous and papillary differentiation and was staged as G3pT1B with the infiltration of the superficial part of the bottom of the chorion. The patient underwent a transurethral resection of the bladder and had a course of intravesical injections of Bacillus Calmette-Guerin (BCG).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
Too often of late we talk about mental health only in the context of the most recent mass shooting. “It just shows we need to focus more on mental health,” is a common refrain. We do need to focus more on mental health, but not because of these tragic shootings. We need to focus on mental health because for far too long we’ve ignored it. Consider this: if you learned you had cancer, you’ d likely be quick to tell family and friends what you’re dealing with. However, if the diagnosis is…
Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
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