Mitochondrial dysfunction and cerebral metabolic abnormalities in patients with mitochondrial encephalomyopathy subtypes: Evidence from proton MR spectroscopy and muscle biopsy.

CONCLUSIONS: Mitochondrial cytopathy (lactic acidosis and RRFs on muscle biopsy) was associated with neuronal viability but not glial proliferation, notably in MELAS. Mitochondrial neuronopathy and neuronal vulnerability are considered significant causes in the pathogenesis of MELAS, particularly with regard to stroke-like episodes. PMID: 28695670 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28695670?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - July 11, 2017 Category: Neuroscience Authors: Niu FN, Meng HL, Chang LL, Wu HY, Li WP, Liu RY, Wang HT, Zhang B, Xu Y Tags: CNS Neurosci Ther Source Type: research