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Asbestos Type Has No Effect on Mesothelioma Latency Period

New research from scientists in Germany sheds more light on the unusually long latency period associated with mesothelioma and other asbestos-related diseases. The study, published earlier this year in the European Respiratory Journal, is the first to track the presence of asbestos fibers in lung tissue over time. Mesothelioma has one of the longest latency periods of any cancer. It typically takes anywhere from 20 to 50 years after a person’s initial exposure to asbestos before symptoms arise. Using the German Mesothelioma Register, researchers at Ruhr-University Bochum discovered the volume of asbestos fibers in tissue does not decrease over time, regardless of the type of asbestos involved. Specifically, the concentration of chrysotile — the most common of the six types of asbestos — remained stable over time, despite some previous studies suggesting it may be easier for the body to rid itself of that particular type of the naturally occurring mineral. “Our results show that asbestos continues to be demonstrable in human lungs, that also chrysotile can be identified after many years, and that there is no significant reduction of asbestos fibre concentrations in lung tissues over time after exposure cessation,” lead researcher Inke Sabine Feder wrote in the study. “The unique benefit of the data presented here is to have a measured starting point of the asbestos fibre burden of the human lung tissue to compare later findings with.&rd...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: amosite amphibole asbestos exposure asbestos fiber burden asbestos fibers in lungs biopersistence of asbestos bronchoalveolar lavage Chrysotile asbestos Chrysotile asbestos fibers European Respiratory Journal German Mesothelioma Regist Source Type: news

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Pemetrexed, a multitargeted antifolate cytotoxic agent, is currently used primarily in combination with cisplatin for metastatic non-small cell lung cancer and for malignant mesothelioma. Acute renal toxicity ...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
A new mesothelioma clinical nurse specialist has been appointed to support the high number of patients with the condition across Merseyside and Cheshire.
Source: Nursing Times - Category: Nursing Source Type: news
New York City Police Commissioner James O’Neill recently appointed mesothelioma specialist Dr. Raja Flores to the Society of Honorary Police Surgeons. The prestigious appointment stems from Flores’ continued, long-running service to so many first responders — particularly policemen and firemen from the 9/11 World Trade Center (WTC) terrorist attack in 2001. Although Flores has received many honors throughout his medical career, this one might be his most appreciated. “This is a huge honor for me,” Flores told Asbsetos.com. “I come from a family of cops. Police work is in my blood. My gra...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: 9/11 9/11-related cancer James O’Neill Mount Sinai Hospital New York City Police Commissioner NYPD Raja Flores Society of Honorary Police Surgeons twin towers World Trade Center World Trade Center Health Program Source Type: news
CONCLUSION: Increases in leukemia and urinary cancer but not lung cancer mortality were found. One death attributed to mesothelioma was observed in a worker with self-reported asbestos exposure and a work history where occupational asbestos exposure may have occurred, rendering uncertainties in assigning causation. Radiographic analyses indicated RCF exposure alone is associated with increased pleural but not interstitial changes. Reductions in RCF exposure should continue. The mortality study is ongoing. PMID: 29124996 [PubMed - in process]
Source: Inhalation Toxicology - Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research
AbstractThis review considers the “promise” of exploiting the proton-coupled folate transporter (PCFT) for selective therapeutic targeting of cancer. PCFT was discovered in 2006 and was identified as the principal folate transporter involved in the intestinal absorption of dietary folates. The recognition that PCFT was highly ex pressed in many tumors stimulated substantial interest in using PCFT for cytotoxic drug targeting, taking advantage of its high level transport activity under the acidic pH conditions that characterize many tumors. For pemetrexed, among the best PCFT substrates, transport by PCFT establ...
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
U.S. Sen. Jeff Merkley, D-Ore., introduced legislation in Congress this week that would effectively ban all use of asbestos. The Alan Reinstein Ban Asbestos Now Act of 2017 is the sixth legislative attempt to ban the toxic substance in the last 20 years. All previous bills failed to gain enough support. While the 2016 Toxic Substances Control Act (TSCA) already includes asbestos on its top ten chemicals for risk review by the Environmental Protection Agency (EPA), Merkley’s legislation could speed the process considerably. What Would the Bill to Ban Asbestos Do? According to Merkley’s congressional office, the ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Alan Reinstein Ban Asbestos Now Act asbestos ban Cory Booker environmental protection agency EPA Jeff Merkley Jon Tester Raja Flores Steve Daines Toxic Substances Control Act TSCA u.s. congress Source Type: news
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
In this study, we investigated podoplanin expression in 40 feline squamous cell carcinomas (14 cases of mouth floor, 13 of skin, 9 of ear, and 4 of tongue) by immunohistochemical analysis using an anti-cat podoplanin mAb PMab-52, which we recently developed by cell-based immunization and screening (CBIS) method. Of the total 40 cases, 38 (95%) showed positive staining for PMab-52. In particular, 12 cases (30%) showed a strong membrane-staining pattern of squamous cell carcinoma cells. PMab-52 can be useful for antibody therapy against feline podoplanin-expressing squamous cell carcinomas. PMID: 29090969 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Authors: Kim YR, Song MH, Lee JW, Bae JH, Kim JE, Kang DM, Lee SY Abstract Serological analysis of recombinant tumor cDNA expression library (SEREX) is a powerful and widely used method to explore the cancer immune environment. In the present study, immunoscreening of normal testicular tissues and malignant mesothelioma (MM) cancer MSTO-211H cell line cDNA libraries with sera from 5 MM patients led to the isolation of 16 independent antigens, which were designated 'Korea Pusan-Malignant Mesothelioma' (KP-MM)-1 to -16. In total, 3/16 antigens were identified using the results of previous SEREX analyses, and 13 were ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Shares in Novocure (NSDQ:NVCR) are on the rise today after the medical device maker topped revenue and losses-per-share expectations on Wall Street with its 3rd quarter earnings results. The St. Helier, N.J.-based company posted losses of $11.5 million, or 13¢ per share, on sales of $50.1 million for the 3 months ended September 30, seeing losses on the bottom-line shrink 65.8% while sales grew 131.2% compared with the same period during the previous fiscal year. Losses per share for the quarter came in under the 17¢ consensus on Wall Street, while sales beat the $43.6 million expectations on The Street. &ld...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News MassDevice Earnings Roundup NovoCure Source Type: news
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