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Asbestos Type Has No Effect on Mesothelioma Latency Period

New research from scientists in Germany sheds more light on the unusually long latency period associated with mesothelioma and other asbestos-related diseases. The study, published earlier this year in the European Respiratory Journal, is the first to track the presence of asbestos fibers in lung tissue over time. Mesothelioma has one of the longest latency periods of any cancer. It typically takes anywhere from 20 to 50 years after a person’s initial exposure to asbestos before symptoms arise. Using the German Mesothelioma Register, researchers at Ruhr-University Bochum discovered the volume of asbestos fibers in tissue does not decrease over time, regardless of the type of asbestos involved. Specifically, the concentration of chrysotile — the most common of the six types of asbestos — remained stable over time, despite some previous studies suggesting it may be easier for the body to rid itself of that particular type of the naturally occurring mineral. “Our results show that asbestos continues to be demonstrable in human lungs, that also chrysotile can be identified after many years, and that there is no significant reduction of asbestos fibre concentrations in lung tissues over time after exposure cessation,” lead researcher Inke Sabine Feder wrote in the study. “The unique benefit of the data presented here is to have a measured starting point of the asbestos fibre burden of the human lung tissue to compare later findings with.&rd...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: amosite amphibole asbestos exposure asbestos fiber burden asbestos fibers in lungs biopersistence of asbestos bronchoalveolar lavage Chrysotile asbestos Chrysotile asbestos fibers European Respiratory Journal German Mesothelioma Regist Source Type: news

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High resolution computed tomography, (HRCT), is currently considered the diagnostic gold standard to diagnose early stage malignant pleural mesothelioma and other non-malignant pleural conditions, but it is expensive and exposes the patient to radiation dose. In a screening and population medicine perspective, Thoracic Ultrasounds may become a valuable alternative because it can detect minimal changes in pleural surface, is widely available and safe.On these bases, we therefore validated thoracic US in subjects with history of exposure to asbestos, having HRCT as the reference standard.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
A drug used to treat bone disease and high blood calcium levels may carry benefits as part of a combination treatment for malignant pleural mesothelioma, a recent study concluded. Researchers at the University of Alabama at Birmingham Comprehensive Cancer Center conducted a pilot study testing the effects of zoledronic acid — a bisphosphonate, or bone health drug, marketed as Reclast and Zometa — against a small group of patients with unresectable pleural mesothelioma. The study, published in the June edition of Lung Cancer: Targets and Therapy journal, was a follow-up to preclinical research showing zoledron...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: bone disease treatment keytruda mesothelioma treatments Muhammad Omer Jamil reclast treating malignant pleural mesothelioma University of Alabama at Birmingham Comprehensive Cancer Center Zoledronic acid zometa Source Type: news
Authors: Rimkus T, Sirkisoon S, Harrison A, Lo HW Abstract Tumor suppressor candidate 2 (TUSC2, also known as FUS1) was identified in 2000 as a candidate tumor suppressor gene located in a region on chromosome 3p21.3 that is homozygously deleted in some lung and breast cancers. The deletion is rare in lung and breast cancers, but is frequent in malignant pleural mesothelioma. Evidence to date indicates that TUSC2 behaves as a tumor suppressor in lung cancer; however, its role as a tumor suppressor for other tumor types has not been fully established. Loss of TUSC2 expression at the mRNA and protein levels has been ...
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research
Justice, a national retail chain marketed to young girls, has stopped selling a cosmetics product after discovering it contained talc contaminated with asbestos fibers. The government-licensed Scientific Analytical Institute (SAI) in Greensboro, North Carolina, confirmed the asbestos contamination after testing the product as part of a Durham-based WTVD-TV news investigation. The tainted product was Just Shine Shimmer Powder, which the company stopped selling at stores and removed from its website, according to a Tuesday post on its Facebook page. “Our suppliers are required to produce all products in compliance wit...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: asbestos contaminates makeup asbestos in children's makeup asbestos in makeup asbestos in products asbestos in talcum powder asbestos in toys makeup with asbestos Source Type: news
Source: Lung Cancer - Category: Cancer & Oncology Authors: Tags: Short communication Source Type: research
In this study, chrysotile from Mangnai, Qinghai, China, and an artificial substitute, rock wool fiber were prepared as suspensions and were tested at concentrations of 50, 100, and 200 μg/ml in V79 lung fibroblasts. Chromosome aberrations were detected by micronucleus assay after exposure for 24 h, and DNA damage were estimated by single cell gel electrophoresis after exposure for 12, 24, or 48 h. According to the results, chrysotile and rock wool fibers caused micronuclei to form in a dose-dependent manner in V79 cells; olive tail moment values increased in a dose- and time-dependent manner. When V79 cel...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
Conclusions: We confirmed the lack of association between exposure to asbestos-free talc, lung cancer, and mesothelioma. Increased mortality from pneumoconiosis among miners is attributable to past exposure to silica.
Source: Journal of Occupational and Environmental Medicine - Category: Occupational Health Tags: Original Articles Source Type: research
The Seattle Cancer Care Alliance has opened a phase II clinical trial involving durvalumab, the promising immunotherapy drug, in combination with chemotherapy for the first-line treatment of unresectable pleural mesothelioma. The U.S. Food and Drug Administration (FDA) already granted accelerated approval to durvalumab in May for the treatment of bladder cancer. Researchers have also lauded the drug for its effectiveness in earlier lung cancer clinical trials. “We have every reason to believe it will be effective with mesothelioma, too,” Dr. Bernardo Goulart, chief trial investigator and medical oncologist at t...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: cancer in seattle doctor Bernardo Goulart mesothelioma clinical trials mesothelioma in seattle mesothelioma treatment seattle cancer care alliance Source Type: news
Adding nintedanib to pemetrexed/cisplatin improved the progression-free survival of patients with malignant pleural mesothelioma compared with placebo.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: Lung Cancer News Source Type: news
AbstractIntroductionMalignant pleural mesothelioma (MPM) is a rare cancer that affects the thin cell wall lining of internal organs and structures. Studies have shown that patients with lung cancer have decreased pulmonary function and exercise capacity after pneumonectomy. However, to date, physical function and health-related quality of life (HRQOL) in surgically treated MPM patients have not been evaluated in detail. The aim of this study was to assess physical function and HRQOL of MPM patients following pleurectomy/decortication (P/D).MethodsThe subjects were 22 MPM patients (20 men and 2 women) who completed P/D betw...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
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