Branched-chain amino acid catabolism rather than amino acids plasma concentrations is associated with diet-induced changes in insulin resistance in overweight to obese individuals

3-hydroxyisobutyrate (3-HIB), a catabolic intermediate of the BCAA valine, which stimulates muscle fatty acid uptake, has been implicated in the pathogenesis of insulin resistance. We tested the hypothesis that circulating 3-HIB herald insulin resistance and that metabolic improvement with weight loss are related to changes in BCAAs and 3-HIB.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 10, 2017 Category: Nutrition Authors: S. Haufe, S. Engeli, J. Kaminski, H. Witt, D. Rein, B. Kamlage, W. Utz, J.C. Fuhrmann, V. Haas, A. M ähler, J. Schulz-Menger, F.C. Luft, M. Boschmann, J. Jordan Source Type: research