Replacement therapy with levothyroxine modulates platelet activation in recently onset post-thyroidectomy subclinical hypothyroidism

Subclinical hypothyroidism has been linked to increased risk of atherosclerotic disease. Soluble CD40 ligand (sCD40L), mainly derived from activated platelets, and the lipid peroxidation product 8-iso-prostaglandin F2 α (8-iso-PGF2α) are known to play a relevant pathophysiological role in atherogenesis. Herein we analyzed the relationship between thyroid hormones and circulating levels of sCD40L and 8-iso-PGF2α in patient with recently onset post-thyroidectomy subclinical hypothyroidism under replacement thera py.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 10, 2017 Category: Nutrition Authors: Giovambattista Desideri, Raffaella Bocale, Annamaria D ’Amore, Stefano Necozione, Mauro Boscherini, Giulia Carnassale, Angelina Barini, Antonella Barini, Rocco Bellantone, Celestino Pio Lombardi Source Type: research