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How to hack your gut to ward off Parkinson's and obesity

Jasenka Zubcevic and Christopher Martynuik work in Physiological Sciences and Toxicology at the University of Florida. Here they explain everything we know about the gut thus far...
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In conclusion, the connection between DNA damage and aging is emphasized by the secretion of senescence-associated proteins during cellular senescence, a phenotype which is activated by DNA damage and is common for both human and mice. Though much progress has been achieved, full understanding of these mechanisms has still a long way to go. XPO1 as a Novel Target for Therapies to Enhance Autophagy https://www.fightaging.org/archives/2018/05/xpo1-as-a-novel-target-for-therapies-to-enhance-autophagy/ Autophagy is the name given to a collection of cellular housekeeping processes that recycle damaged and un...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This article originally appeared on Health.com
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition healthytime onetime Source Type: news
Abstract Recent studies indicate that metabolic disorders such as diabetes and obesity are a major risk factor of psychiatric diseases. This relationship opens the opportunity to develop new antidepressant drugs by repurposing antidiabetic drugs. Previous research has demonstrated that GLP-1 analogs are neuroprotective in several neurological disease models including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke. In addition, the GLP-1 analog liraglutide has been shown to promote neurogenesis, which is seen to play important roles in memory formation and cognitive and emotional processing. However...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Quantitative assessment of physical activities during daily life plays a significant role in evaluating the functional ability and the level of activity in healthy individuals and patients suffering from obesity, recurrent falling, Parkinson's disease, and back pain [1 –5]. In recent years, wearable inertial sensors with lightweight, long battery life, and large memory have become increasingly popular for ambulatory human motion analysis [6,7]. Najafi et al. [4,8] adopted the trunk inclination angle, obtained from the integration of the angular velocity and disc rete wavelet transform (DWT), to detect postural transi...
Source: Medical Engineering and Physics - Category: Biomedical Engineering Authors: Tags: Technical note Source Type: research
Using functional connectivity MRI (fcMRI) scans to show how various brain networks...Read more on AuntMinnie.comRelated Reading: MRI finds obesity trigger in obese kids MRI shows bicycling may help patients with Parkinson's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractOverall Abstract: The brain-gut-microbiota axis is emerging as a research area of increasing interest for those investigating the biological and physiological basis of neurodevelopmental, age-related and neurodegenerative disorders. The routes of communication between the gut and brain include the vagus nerve, the immune system, tryptophan metabolism, via the enteric nervous system or by way of microbial metabolites such as short chain fatty acids. These mechanisms also impinge on neuroendocrine function at multiple levels. Studies in animal models have been key in delineating that neurodevelopment and the programm...
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research
Abstract BACKGROUND: The phosphodiesterase 10 (PDE10) family, identified in 1999, is mainly expressed in the brain, particularly in the striatum, within the medium spiny neurons, nucleus accumbens, and olfactory tubercle. Inhibitors of PDE10 (PDE10-Is) are a conceptually rational subject for medicinal chemistry with potential use in the treatment of psychiatric and neurodegenerative diseases. OBJECTIVE: This review is based on peer-reviewed published articles, and summarizes the cellular and molecular biology of PDE10 as a rational target for psychiatric and neurodegenerative drug discovery. Here we present t...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
Where should the line be drawn when deciding whether or not to adopt disruptive technologies? As digital health brings up plenty of ethical questions, legal issues, and safety concerns, The Medical Futurist Institute decided to collect the best examples of how governments worldwide tried to adopt digital health. We hope it inspires other policy-makers to take the first steps in shaping their healthcare regulations. Our common goal is to arrive at a better future of healthcare Disruptive technologies spread around like wildfire, but healthcare systems are crumbling under the pressure of problems and changes. So, The Medical...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Digital Health Research Healthcare Policy digital health strategy digital innovation future health policy Medicine technology Source Type: blogs
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