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How to hack your gut to ward off Parkinson's and obesity

Jasenka Zubcevic and Christopher Martynuik work in Physiological Sciences and Toxicology at the University of Florida. Here they explain everything we know about the gut thus far...
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In Westwood, more than 100 faculty experts from 25 departments have embarked on anall-encompassing push to cut the health and economic impacts of depression in half by the year 2050. The mammoth undertaking will rely on platforms developed by the new Institute for Precision Health, which will harness the power of big data and genomics to move toward individually tailored treatments and health-promotion strategies.On the same 419 acres of land, researchers across the spectrum, from the laboratory bench to the patient bedside, are ushering in a potentially game-changing approach to turning the body ’s immune defenses a...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Novel anti-adipogenic activity of anti-malarial amodiaquine through suppression of PPARγ activity. Arch Pharm Res. 2017 Oct 25;: Authors: Kim TH, Kim HK, Hwang ES Abstract Amodiaquine (AQ) was developed as a selective drug against Plasmodium falciparum malaria infection and has received increasing attention as a therapeutic agent for the treatment of rheumatoid arthritis, Parkinson's disease, and cancer due to its anti-inflammatory, anti-proliferative, and autophagic-lysosomal blockade properties. As autophagy activation is involved in promoting adipogenic differentiation, we examined whether an...
Source: Archives of Pharmacal Research - Category: Drugs & Pharmacology Authors: Tags: Arch Pharm Res Source Type: research
The U.S. Food and Drug Administration is supposed to be protecting our food supply. But the sad truth is that it does very little to monitor what chemicals go into your food. And even when there’s science to prove the health risks of new ingredients, they drag their feet. It can take years… or even decades… before they pull harmful additives from the market.  When a processor wants to add a new chemical to food, the FDA doesn’t require any testing. The food company just sends a notice to the FDA. The notice says that the ingredient is &;dquo;generally recognized as safe” or GRAS....
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Brain Health Heart Health Men's Health Nutrition Women's Health Source Type: news
Conclusion: Prenatal and early postnatal exposures to p,p′-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5–9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553 Received: 24 May 2016 Revised: 29 August 2017 Accepted: 29 August 2017 Published: 03 October 2017 Address correspondence to A.H. Rosenquist, Department of Clinical Epidemiology, Olof Palmes Allé 43-45, 8200 Aarhus N, De...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusion: Prenatal and early postnatal exposures to p,p′-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5–9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553 Received: 24 May 2016 Revised: 29 August 2017 Accepted: 29 August 2017 Published: 03 October 2017 Address correspondence to A.H. Rosenquist, Department of Clinical Epidemiology, Olof Palmes Allé 43-45, 8200 Aarhus N, De...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Author Affiliations open 1Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands 2Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands 3Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands 4Department of Neurology, Amsterdam Medical Center, University of Amsterdam, Amsterdam, Netherlands 5Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, Netherla...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
In this study, we identified dyskinesias reduction and distance between the active electrodes and the third ventricle as determining factors of weight gain after STN-DBS implantation in PD patients. The first finding coul d be linked to a decrease in energy consumption, while the second one could be due to a lower stimulation of the lateral hypothalamic area, known for its important role in metabolism and body weight control. Weight gain is a common finding after STN-DBS implantation, and it should be carefully monit ored given the potential harmful consequences of overweight.
Source: Neurological Sciences - Category: Neurology Source Type: research
This study developed the first procedure for the removal of epithelium from the lung airway with the full preservation of vascular epithelium, which could be applied in vivo to treat diseases of lung epithelium. Whole lung scaffolds with an intact vascular network may also allow for recellularization using patient-specific cells and bioengineering of chimeric lungs for transplantation. In addition to the clinical potential, lung scaffolds lacking an intact epithelial layer but with functional vascular and interstitial compartments may also serve as a valuable physiological model for investigating (i) lung development, (ii)...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(Bentham Science Publishers) This review focuses on four modifiable risk factors including physical inactivity, vascular disease-related conditions, obesity and type two diabetes mellitus, all of which have been identified as risk factors for the development of Alzheimer's disease (AD) and Parkinson's disease (PD).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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