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Toxic metal hip replacements could cause Alzheimer's

Dr Neil McGuire, clinical director of medical devices at the MHRA, said he wanted to establish whether cobalt leached from the implants was causing adverse effects.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Renn BN, Asghar-Ali AA, Thielke S, Catic A, Martini SR, Mitchell BG, Kunik ME Abstract Cholinesterase inhibitors (ChEIs) are the primary pharmacological treatment for symptom management of Alzheimer disease (AD), but they carry known risks during long-term use, and do not guarantee clinical effects over time. The balance of risks and benefits may warrant discontinuation at different points during the disease course. Indeed, although there is limited scientific study of deprescribing ChEIs, clinicians routinely face practical decisions about whether to continue or stop medications. This review examined publ...
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
CONCLUSIONS: The association between BMI and dementia is likely to be attributable to two different processes: a harmful effect of higher BMI, which is observable in long follow-up, and a reverse-causation effect that makes a higher BMI to appear protective when the follow-up is short. PMID: 29169013 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Guide to making heritage more dementia-friendly launched with support of Alzheimer ’s Society Ambassador Sir Tony Robinson.
Source: Alzheimers Society - Category: Geriatrics Source Type: news
CONCLUSIONS: The study focused on reviewing the literature for mainly three cognitive rehabilitation strategies: (1) rehearsal-based approaches (2) compensatory techniques (3) mnemonic strategies. In the present review, rehabilitation of language deficits in MCI is also included. PMID: 29165763 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSION: If bioavailability constraint is overcome, diseases like cancer, alzheimer, diabetes, liver disorder etc. can be effectively targeted. By doing so, the largely affected society, will breathe the relief. The present article is an attempt to elaborate and conclude on how nanoparticles have been serving as a tool to enhance the effectiveness of phytochemicals, by solubilization, dissolution and consequent bioavailability enhancements, along with in vivo targeting. To further facilitate understanding, the review has been structured as disease/disorder and phytochemical wise with focus on their nanoparticles. PM...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research
There is a fair amount of evidence from the past decade to show that exercise improves cognitive function in both young and old individuals. A subset of that data points towards increased levels of BDNF as one of the mediating mechanisms. A great deal more work is needed to flesh out the current understanding of the enormously complex biochemistry involved in the effects of exercise on the brain, of course, but that doesn't stop some researchers from optimistically considering pharmaceutical approaches to mimic some of the beneficial effects of exercise. The health advantages of high-intensity exercise are widely ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Alzheimer's disease is an irreversible, progressive brain disorder that accounts for about 50 –75% of all cases of dementia.1 Alzheimer's disease is characterised by the presence of amyloid plaques (amyloid β) and neurofibrillary (tau) tangles, plus the loss of connections between neurons in the brain. The damage to the brain induced by abnormal deposits of amyloid β and tau tangles is b elieved to start a decade or more before a decline in cognitive function is apparent.1,2
Source: LANCET - Category: General Medicine Authors: Tags: Comment Source Type: research
Conclusions Telephone assistance systems are an efficient healthcare resource for monitoring patients with AD in neurology departments. Furthermore, the level of user satisfaction was high. We therefore consider that telephone assistance service should be offered by healthcare services.
Source: Neurologia - Category: Neurology Source Type: research
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
In this study, we aim to systematically investigate the ameliorative effects of dopamine D1-like receptor agonist SKF38393 on cognitive dysfunction and explore its underlying mechanisms. The Aβ1–42 was injected intracerebroventricularly to establish cognitive disorder model. Then, a series of behavior tests were used. In order to further study the mechanisms, some relevant protein was assessed by ELISA method and Western blot. The results in behavior tests revealed that SKF38393 significantly ameliorated all the test indexes compared with the model mice. Then SKF38393 increased phosphorylation of cAMP response e...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
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