Toxic metal hip replacements could cause Alzheimer's
Dr Neil McGuire, clinical director of medical devices at the MHRA, said he wanted to establish whether cobalt leached from the implants was causing adverse effects.
Authors: Lahiri DK, Thakur MK, Maloney B PMID: 28732191 [PubMed - as supplied by publisher]
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Alzheimer's is common, costly and harms patients and their caregivers, but there are no effective treatments to slow the disease. This is bad news for companies. Caregivers are absent and distracted employees. Fortunately, companies can accelerate the pace of studies to discover treatments.
Contributors : Laszlo Nagy ; Zoltan SimandiSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusA growing number of pieces of evidence suggest the importance of Retinoid X Receptor (RXR)-mediated pathways in neurogenesis and the dysregulation of this signaling in neurodegenerative disorders, such as Alzheimer`s or Amyotrophic Lateral Sclerosis. The data presented here identify the RAR:RXR and LXR:RXR-mediated transcriptional program in embryonic stem cells, neural progenitors and terminally differentiated neurons.
For many of us, a car is a sign of independence. But this emotional connection to our automobiles is part of what makes convincing a person that he or she is no longer capable of driving such a volatile battle. The longer adult children or others wait to discuss driving issues with a loved one, the harder it can be. Occasionally, people in the earlier stages of cognitive or physical decline will recognize the signs of that decline when they have a close call while driving and scare themselves into giving up their right to drive. More frequently, if the person has developed Alzheimer’s or another type of dementia, and...
Publication date: Available online 21 July 2017 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Min Ju Kim, Shafiq Ur Rehman, Faiz Ul Amin, Myeong Ok Kim Amyloid-beta (Aβ1–42) plaques and neurofibrillary tangles (NFTs) are the main hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD). Recently, nanoparticle-based targeted drug delivery approaches have been found to be a useful tool in the neurotherapeutics field. Therefore, we examined and compared the neuroprotective effect of anthocyanins alone and anthocyanin-loaded poly (ethylene glycol)-gold nanopart...
In conclusion, the 2‐benzylidene‐1‐tetralone derivatives can be considered as lead compounds to design a new class of dual acting adenosine A1/A2A receptor antagonists that may have potential in treating both dementia and locomotor deficits in Parkinson's disease. This article is protected by copyright. All rights reserved. Substitution of 2‐benzylidene‐1‐tetralone with a hydroxy group on ring A and/or B played a key role in modulating the binding affinity and selectivity for the adenosine A1 and A2A receptors. Generally, C5‐hydroxy substitution on ring A favored A1 affinity, while C4′‐hydroxy substi...
(MedPage Today) -- Carriers of Alzheimer's susceptibility gene have increased risk