Deranged regulatory T-cells and transforming growth factor- & #946;1 levels in type 1 diabetes patients with associated autoimmune diseases

Conclusion: Thus, there was an increased percentage of Tregs and serum levels of TGF-β1 in T1D patients, irrespective of the disease duration and associated autoimmune diseases. The significant correlation in these two parameters at the onset of the disease, but not in LS disease, indicates that the immunological milieu in LS autoimmune diseases is more complicated with disease-associated conditions such as prolonged hyperglycemia, insulin therapy, and/or continued gluten in diet. Treatment and modulation of these long-term complications for improving immunological parameters require further research.
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research