Impact of myeloid cells on the efficacy of anticancer chemotherapy.

Impact of myeloid cells on the efficacy of anticancer chemotherapy.
Curr Opin Immunol. 2014 Jun 17;30C:24-31
Authors: Senovilla L, Aranda F, Galluzzi L, Kroemer G
Abstract
Tumors are not immunologically silent but evolve and respond to therapy in the context of a continuous, bi-directional interaction with the host immune system. In line with this notion, several clinically successful chemotherapeutics have been shown to mediate antineoplastic effects as they (re)activate an anticancer immune response that is generally executed by lymphoid cells. Myeloid cells play a central role in this process, not only because they critically regulate the activity of T and B lymphocytes, but also because they exert direct tumoricidal effects, at least in some settings. Here, we discuss the impact of various myeloid cell populations, including macrophages, dendritic cells and myeloid-derived suppressor cells, on the efficacy of anticancer chemotherapy.
PMID: 24950501 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - June 17, 2014 Category: Allergy & Immunology Authors: Senovilla L, Aranda F, Galluzzi L, Kroemer G Tags: Curr Opin Immunol Source Type: research