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A diagnosis of dysautonomia sheds new light on Sarah ’s pain

Sarah Fishman exudes vivaciousness and warmth. When describing her favorite activities, mainly swimming and rugby, her energy is infectious. It is hard to imagine that someone as lively as Sarah has been suffering from chronic pain her whole life. Since she was little, Sarah has struggled with Irritable Bowel Syndrome (IBS), a common intestinal disorder that causes stomach pain and colon issues. However, it wasn’t until her junior year of college that she started experiencing symptoms that were no longer recognizable. “My local gastroenterologist kept giving me treatments that weren’t doing anything,” Sarah remembers. “So it kind of occurred to me and my parents after a while that maybe this is more of a brain-thing than a stomach-thing.” Sarah started experiencing extreme fatigue, nausea, and vertigo. She tried to write off her symptoms as normal bodily functions, but when the migraines started, she knew something was indisputably wrong. A second opinion from Boston Children’s Hospital Searching for the cause of her new symptoms, Sarah made an appointment with Dr. Alyssa Lebel in the Headache Program at Boston Children’s Hospital. Sarah’s migraines, in addition to her other symptoms, were a key sign to Lebel that something was awry in her autonomic nervous system (ANS). The ANS controls the body’s vital signs, including internal temperature, breathing patterns, blood pressure, heart rate, digestion, and pupil dilati...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Our Patients’ Stories Alyssa Lebel dysautonomia headaches irritable bowel syndrome Source Type: news

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CONCLUSIONS: Non-pharmacological approaches to pain in residential care settings are effective, especially when two or more are combined. Staff working in residential care settings should rely on best practice to recognise pain in residents with dementia. CLINICAL IMPLICATIONS: Non-pharmacological interventions may be effective in reducing pain and reliance on PRN medications in residential care settings, especially when two or more are used. Staff working in residential aged care settings should be provided with training in pain assessment and management, with particular attention to residents with dementia. PMID:...
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
Abstract PURPOSE: To compare the outcome of dental implants placed following full-thickness flap surgery with flapless surgery in controlled type 2 diabetic patients. MATERIALS AND METHODS: A total of 92 controlled type 2 diabetic patients, who needed missing mandibular first molars to be replaced by implants, were selected for a single-centre, parallel group, double-blinded randomised controlled trial. Patients were randomly allocated into two groups: flap (46 patients) vs flapless (46 patients) implant placement. Implants were loaded with metal-ceramic crowns, 4 months after placement in both groups. O...
Source: European Journal of Oral Implantology - Category: Dentistry Authors: Tags: Eur J Oral Implantol Source Type: research
Authors: Xiang A, Cheng K, Shen X, Xu P, Liu S Abstract Although acupuncture is gaining popularity for the treatment of nonspecific pain, the immediate analgesic effect of acupuncture has never been reviewed. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) on disease-related pain to critically evaluate the immediate effect of acupuncture for pain relief. The PubMed and Cochrane Central Register of Controlled Trials databases as well as three Chinese databases including the China National Knowledge Infrastructure (CNKI), Wanfang, and VIP platforms were searched through Novem...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Lee G, Kim W Abstract The Locus Coeruleus (LC) is a small collection of noradrenergic neurons located in the pons. In the brain, noradrenaline (NE) is primarily produced by noradrenergic cell groups in the LC, which is the largest group of noradrenergic neurons in the central nervous system. Acupuncture, including the electroacupuncture which is a modified acupuncture method, is known to be effective in various kinds of diseases, and the involvement of noradrenergic system in the central nervous system has been reported by previous studies. However, on whether acupuncture can modulate the LC neuronal cells...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusions: The BJK remedy extract showed equal clinical efficacy in relieving symptoms of OA knee when compared with diclofenac. PMID: 29234447 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Han M, Sun Y, Su W, Huang S, Li S, Gao M, Wang W, Wang F, Fang Z, Zhao H Abstract Background: Many previous studies have shown the potential therapeutic effect of acupuncture for metabolic syndrome (MetS). However, most of these studies were limited by short durations of observation and a lack of sham acupuncture as control. We designed a randomized controlled trial, used sham acupuncture as the control, and evaluated the efficacy over 12 weeks of treatment and 12 weeks of follow-up. Methods/Design: The study was designed as a multicentre, parallel-group, randomized, double-blinded trial. 40 patients w...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Kemmler W, Weissenfels A, Bebenek M, Fröhlich M, Kleinöder H, Kohl M, von Stengel S Abstract In order to evaluate the favorable effect of whole-body electromyostimulation (WB-EMS) on low back pain (LBP), an aspect which is frequently claimed by commercial providers, we performed a meta-analysis of individual patient data. The analysis is based on five of our recently conducted randomized controlled WB-EMS trials with adults 60 years+, all of which applied similar WB-EMS protocols (1.5 sessions/week, bipolar current, 16-25 min/session, 85 Hz, 350 μs, and 4-6 s impuls...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Lv M, Zhang M, Cheng Y, Zhang K, Hou C, Chen X Abstract Semen Strychni have been shown to have therapeutic effect in improving blood circulation, relieving rheumatic pain, and treating cancer. However, Semen Strychni could cause severe nephrotoxicity. The present study was designed to evaluate whether treatment with total glucosides from paeony (TGP) has renoprotective effect against nephrotoxicity induced by total alkaloids from Semen Strychni (TAS). The levels of blood urea nitrogen (BUN) and creatinine (Cr) were determined and histopathological changes were also examined to evaluate renal injury. Moreov...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
This study aimed to evaluate the clinical analgesic efficacy and identify the molecular targets of XGDP for treating primary dysmenorrhea (PD) by a network pharmacology approach. Analysis of pain disappearance rate of XGDP in PD treatment was conducted based on data from phase II and III randomized, double-blind, double-simulation, and positive parallel controlled clinical trials. The bioactive compounds were obtained by the absorption, distribution, metabolism, and excretion processes with oral bioavailability (OB) and drug-likeness (DL) evaluation. Subsequently, target prediction, pathway identification, and network cons...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Park S, Lee JH, Yang EJ Abstract Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles, and severe functional deficits in the brain. The pathogenesis and treatment of AD remain topics of investigation and significant global socioeconomic issues. The effect of complementary medicine has been investigated in managing AD. Acupuncture, a form of therapy practiced for more than 3000 years, has shown positive effects on several neurological disorders including AD. Animal studies have evaluated the specific util...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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