Emerging Roles of Protein Kinases in Microglia-mediated Neuroinflammation.
Emerging Roles of Protein Kinases in Microglia-mediated Neuroinflammation. Biochem Pharmacol. 2017 Jul 03;: Authors: Lee SH, Suk K Abstract Neuroinflammation is mediated by resident central nervous system glia, neurons, peripherally derived immune cells, blood-brain barrier, and inflammatory mediators secreted from these cells. Neuroinflammation has been implicated in stroke and neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis. Protein kinases have been one of the most exploited therapeutic targets in the current pharmacological research, especially in studies on cancer and inflammation. To date, 32 small-molecule protein kinase inhibitors have been approved by the United States Food and Drug Administration for the treatment of cancer and inflammation. However, there is no drug effectively targeting neuroinflammation and/or neurodegenerative diseases. Recent studies have advanced several protein kinases as important drug targets in neuroinflammation and/or neurodegenerative diseases. Here, we review emerging protein kinases potentially involved in neuroinflammation and subsequent neurodegenerative diseases. PMID: 28684305 [PubMed - as supplied by publisher]
Antonio Macci ò, Silvia Busquets, Clelia Madeddu, Josep M. Argilés
Nikitas N. Nomikos, Pantelis T. Nikolaidis, Caio V. Sousa, Apostolos E. Papalois, Thomas Rosemann, Beat Knechtle
CONCLUSIONS: Patients with STEMI or HF can safely tolerate intra-arterial CCB during radial catheterization. PMID: 30555053 [PubMed - as supplied by publisher]
Publication date: Available online 17 December 2018Source: Redox BiologyAuthor(s): Jayshree Hirpara, Jie Qing Eu, Joanna Kia Min Tan, Andrea L. Wong, Marie-Veronique Clement, Kong Li Ren, Naoto Ohi, Takeshi Tsunoda, Jianhua Qu, Boon Cher Goh, Shazib PervaizAbstractThe ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime. Here we report evidence of enhanced reliance on mitochondrial oxidative phosphorylation (OXPHOS) in oncogene-ad...
Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C8CP07211F, PaperBin Li, Ran Zhang, Xinghua Shi Fibrillation of amyloid peptides induces human diseases such as Alzheimer ’s disease, which has become a huge challenge. Some nanoparticles (NPs) could enhance the peptide fibrillations by decreasing the lag time,... The content of this RSS Feed (c) The Royal Society of Chemistry
Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C8CP06971A, PaperAlexander Foote, Lydia H Manger, Michael R Holden, Martin Margittai, Randall H Goldsmith Intrinsically disordered proteins (IDPs) are crucial to many cellular processes and have been linked to neurodegenerative diseases. Single molecules of tau, an IDP associated with Alzheimer ’s disease, are trapped in... The content of this RSS Feed (c) The Royal Society of Chemistry
Dalton Trans., 2019, Advance Article DOI: 10.1039/C8DT03266A, PaperLeila Tabrizi, Lukman O. Olasunkanmi, Olatomide A. Fadare The cyclometalated ruthenium(II) complex was synthesized and studied for cytotoxicity. The interaction of Ru(II) complex with COX-2 was studied by experimental and molecular docking. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019,55,63-66 DOI: 10.1039/C8CC08866G, CommunicationYan Li, Longjie Li, Xunbo Lu, Yulong Bai, Yufan Wang, Yuzhou Wu, Fangrui Zhong Inspired by the heme iron-catalyzed radical insertion of dioxygen to the tryptophan indole ring, herein we utilize alkylperoxy radical species as a coupling partner to trigger a peroxycyclization of readily accessible tryptophan derivatives and enable the first synthesis of peroxypyrroloindolenines. The content of this RSS Feed (c) The Royal Society of Chemistry
Analyst, 2019, Advance Article DOI: 10.1039/C8AN02092B, PaperAritri Ghosh, Sreyan Raha, Susmita Dey, Kabita Chatterjee, Amit Roy Chowdhury, Ananya Barui FTIR spectroscopy and Raman spectroscopy of biological analytes are increasingly explored as screening tools for early detection of cancer. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harveste...