Emerging Roles of Protein Kinases in Microglia-mediated Neuroinflammation.

Emerging Roles of Protein Kinases in Microglia-mediated Neuroinflammation. Biochem Pharmacol. 2017 Jul 03;: Authors: Lee SH, Suk K Abstract Neuroinflammation is mediated by resident central nervous system glia, neurons, peripherally derived immune cells, blood-brain barrier, and inflammatory mediators secreted from these cells. Neuroinflammation has been implicated in stroke and neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis. Protein kinases have been one of the most exploited therapeutic targets in the current pharmacological research, especially in studies on cancer and inflammation. To date, 32 small-molecule protein kinase inhibitors have been approved by the United States Food and Drug Administration for the treatment of cancer and inflammation. However, there is no drug effectively targeting neuroinflammation and/or neurodegenerative diseases. Recent studies have advanced several protein kinases as important drug targets in neuroinflammation and/or neurodegenerative diseases. Here, we review emerging protein kinases potentially involved in neuroinflammation and subsequent neurodegenerative diseases. PMID: 28684305 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research

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Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Felix Preisser, Elio Mazzone, Sebastiano Nazzani, Marco Bandini, Zhe Tian, Michele Marchioni, Thomas Steuber, Fred Saad, Francesco Montorsi, Shahrokh F. Shariat, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I. KarakiewiczAbstractCytoreductive radical prostatectomy (CRP) may offer a survival advantage, according to several retrospective analyses. However, few data are available regarding the morbidity of radical prostatectomy in the metastatic setting. We addressed intra- and postoperative complications of CRP relative to radical prosta...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Ilaria Cavarretta, Nicasio Mancini, Andrea Salonia
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 20 July 2018Source: European UrologyAuthor(s): Atiqullah Aziz, Matthias May, Oliver W. Hakenberg, Sabine D. Brookman-May
Source: European Urology - Category: Urology & Nephrology Source Type: research
By SAURABH JHA Medical Imaging and the Price of Corn After the Napoleonic wars, the price of corn in England became unaffordable. The landowners were blamed for the high price, which some believed was a result of the unreasonably high rents for farm land. Economist David Ricardo disagreed. According to Ricardo, detractors had the directionality wrong. It was the scarcity of corn (the high demand relative to its supply) that induced demand for the most fertile land. That is, the rent did not increase the price of corn. The demand for corn raised the rent. Rent was a derived demand. Directionality is important. Getting direc...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
CONCLUSIONThe significance of BDR for pT2 or higher advanced GBC without biliary infiltration was equivocal because the patients received no survival benefit by undergoing BDR.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 20 July 2018Source: European Journal of Surgical OncologyAuthor(s): Maria Anna Smolle, Michael Parry, Lee Jeys, Seggy Abudu, Robert GrimerAbstractObjectivesSynovial sarcoma, a distinct subtype of soft tissue sarcomas (STS), is typically found in young patients. Long history of symptoms and heterogeneous clinical presentation sometimes delays diagnosis. Children have been reported to have a better prognosis than adults in some series.The main emphasis of this study was to determine differences between children and adults and to investigate prognostic factors regarding cancer specific survi...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionTPE is an invasive treatment for rectal cancer with high 30-day mortality in elderly patients. Oncological outcomes are similar in elderly and younger patients. Therefore, TPE should not be withheld because of high age only, but careful patient selection is needed.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsThe nomograms were able to more accurately predict 3- and 5-year OS and CSS of patients with GISTs than were existing models.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: Available online 20 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Sanjeevan Muruganandan, Maree Azzopardi, Deirdre B Fitzgerald, Ranjan Shrestha, Benjamin C H Kwan, David C L Lam, Christian C De Chaneet, Muhammad Redzwan S Rashid Ali, Elaine Yap, Claire L Tobin, Luke A Garske, Phan T Nguyen, Christopher Stanley, Natalia D Popowicz, Christopher Kosky, Rajesh Thomas, Catherine A Read, Charley A Budgeon, David Feller-Kopman, Nick A MaskellSummaryBackgroundIndwelling pleural catheters are an established management option for malignant pleural effusion and have advantages over talc slurry pleurode...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harveste...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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