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Confirmation of recent heroin abuse: accepting the challenge - Maas A, Madea B, Hess C.

Confirmation or exclusion of recent heroin consumption is still one of the major challenges for forensic and clinical toxicologists. A great variety of biomarkers is available for heroin abuse confirmation, including various opium alkaloids (e.g. morphine,...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

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CONCLUSIONS: The percutaneous placement of a Denver shunt is a technically feasible and effective method for symptomatic relief of refractory ascites. PMID: 28925475 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Takeda A, Irahara A, Nakano A, Takata E, Koketsu Y, Kimata K, Senda E, Yamada H, Ichikawa K, Fujimori T, Sumida Y Abstract The patient was a 67-year-old woman with type 2 diabetes and non-alcoholic steatohepatitis (NASH). The administration of the sodium-glucose cotransporter 2 (SGLT2) inhibitor, ipragliflozin improved her liver dysfunction clinically and histologically. The serum alanine aminotransferase (ALT) and ferritin levels decreased to normal limits after treatment for four months. Type IV collagen and hyaluronic acid, both of which were serum fibrotic markers, decreased after treatment. Ultrasonog...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
I first want to thank you guys for your input in advance. As you can tell, I have been a nervous wreck about this situation and am not quite sure how to proceed. Believe me... I've scoured SDN and other sites to look for an answer, but it is a relatively unique situation and I've gotten good advice from friends and program directors. So here it goes. I am applying for an internal medicine fellowship, however, during residency, I was arrested and charged with a DUI and it's NOT with alcohol,... Applying for fellowship with a DUI charge (not what you think)
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
The new WHO guidelines on prevention of surgical site infections1 recommend chlorhexidine-alcohol rather than aqueous povidone-iodine or povidone-iodine with alcohol for surgical skin preparation. This recommendation was provided as a “strong recommendation” with “low to moderate” quality of evidence. One of us (AFW) was a member of the guidelines development group that formulated the WHO recommendations. However, we are now concerned with the completeness and quality of the evidence that led to the chlorhexidine-alcohol recommendation.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research
Matthias Maiwald and Andreas Widmer express concern with the WHO recommendation on surgical site preparation.1,2 WHO guidelines are developed using processes and methods to ensure robust recommendations.3 Specifically, this recommendation was informed by a systematic review and several meta-analyses, including one of six randomised controlled trials comparing alcohol-based chlorhexidine with povidone-iodine-alcohol (PVP-I) preparations that showed a greater reduction in surgical site infections (SSIs) with chlorhexidine (odds ratio [OR] 0 ·58, 95% CI 0·42–0·80).
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research
This study demonstrates that OXLAM-mediated induction of a proinflammatory response in macrophages is one of the potential mechanisms underlying the progression from alcohol-induced steatosis to alcoholic steatohepatitis. PMID: 28923202 [PubMed - in process]
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
Review of five drugs – including one linked to deaths – says there is no body of reliable evidence behind any of themThere is no magic pill to cure alcoholism, according to a scientific review of the evidence of five drugs being prescribed by doctors.None of the five drugs has a body of reliable evidence behind it, say the scientists, even though one of the drugs, nalmefene, has been approved for use in the NHS by Nice, the National Institute for Health and Care Excellence. Another, baclofen, has generated huge excitement, especially in France, but has been linked to deaths.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Alcoholism Health Society NHS Drugs Pharmaceuticals industry Business Science UK news Source Type: news
(Society for the Study of Addiction) A new study published by the scientific journal Addiction has found no reliable evidence for using nalmefene, naltrexone, acamprosate, baclofen or topiramate to control drinking in patients with alcohol dependence or alcohol use disorder. At best, some treatments showed low to medium efficacy in reducing drinking, but those findings were from studies with a high risk of bias. None demonstrated any benefit on health outcomes.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
(Journal of Studies on Alcohol and Drugs) YouTube videos featuring alcohol are heavily viewed and nearly always promote the 'fun' side of drinking. That's the finding of a study in September issue of the Journal of Studies on Alcohol and Drugs.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Publication date: 15 December 2017 Source:Journal of Membrane Science, Volume 544 Author(s): Santi Khoonsap, Supagorn Rugmai, Wei-Song Hung, Kueir-Rarn Lee, Sujitra Klinsrisuk, Sittipong Amnuaypanich Unique anti-trade-off behavior, i.e., the concomitant increasing of water permeability and water selectivity, was observed in the nanocomposite membranes developed from polyvinyl alcohol incorporated with poly(2-hydroxyethyl methacrylate)-grafted silica nanospheres (PVA/PHEMA-grafted SNSs). Under a certain temperature range (10–30°C) for the pervaporation dehydration of acetone-water solution, increasing of the graf...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
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