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As it pushes forward with its acne drug, Novan's cash dwindles to $30 million

With cash dwindling, Morrisville-based Novan (Nasdaq: NOVN) is continuing to push forward with its nitric-oxide based acne product SB204 on the heels of a leadership change and workforce reduction. Earlier this year, the company announced mixed Phase 3 clinical trial results for SB204, which sent its stock plummeting 75 percent. Shortly thereafter, Novan said it had assembled a team to analyze the data from those trials and that it continues to remain optimistic on the product and a pre-subm ission…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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From hormones to genetics to your skincare regime, adult acne can be triggered by many factors. New research shows this can include what you eat.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Guidelines established by the AAD recommend minimizing the duration of systematic antibiotics for the management of acne to an ideal duration of 3-4 months and no longer than 6 months in order to decrease the risk of resistance. Prior reports in the UK and US have documented that oral antibiotics are often prescribed to treat acne for longer durations that recommended by acne guidelines. We sought to characterize the use of oral antibiotics for the treatment of acne in the pediatric population ages 12 to 22 and the adult population ages 21 to 60.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Acne is known to correlate with masculinizing testosterone (T) therapy use in female-to-male transgender men. However, the timing of acne onset and acne risk factors in this population have not been well-studied. In this retrospective study, we explored the combined effects of T therapy and biological factors on acne development in a population of transgender men that have initiated and maintained therapy for at least two years. We identified 55 transgender men aged ≥18 who received care between January 1, 2008 - December 31, 2017 at Boston Medical Center, MA.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Studies of human skin microbiome suggest that Propionibacterium acnes strains may contribute differently to skin health and disease. In the current study, our aim was to elucidate the phenotype and immune functions of Th17 cells induced by healthy (PH) and acne (PA) skin-associated P. acnes strains, and identify any role played by these cells in host defense against P. acnes. We isolated P. acnes specific-Th17 clones and demonstrate that PH- and not PA-specific Th17 clones secreted molecules sufficient to kill P.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research
Lifestyle factors, such as diet, may contribute to acne occurrence and exacerbation. Although an association between high intake of dairy products and acne has been reported in a European study, the relationship between acne and dairy products in the U.S. has not been fully elucidated. The aim of this study is to assess the frequency and severity of acne (A) in a lactose intolerant (LI) U.S. patient population. A large urban medical record data repository (>5 million patients) was searched (Jan 2001 to Nov 2017) and yielded data for all patients with a diagnosis of both LI (ICD-codes: 271.3, E73.9') and A (ICD-codes: 70...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research
Acne vulgaris is one of the most common dermatologic disorders and may result in profound negative physical and psychosocial side effects including scarring, low self-esteem, depression and suicidal ideation. This intervention aimed to improve child and adolescent acne care given by primary care pediatricians through intensive education of clinicians and implementation of an electronic medical record (EMR) tool. Pediatricians associated with a tertiary-care children ’s hospital healthcare system in San Diego (n=116) underwent intensive, case-based education on acne assessment and treatment based on published acne treatment guidelines.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Background: Acne has various clinical manifestations and should be appropriately treated according to the severity. In Korea, 'Korea Acne Severity Rating System (KAGS)' is a standardized index to identify the status of acne, according to the characteristics of Koreans to determine the severity of acne. In practice, however, there has been a limit to the use of KAGS in clinical settings. Objectives: Our aim was to determine whether the deep convolutional neural networks (CNNs) could assess the severity of acne at the level of competence comparable to dermatologists scoring.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
The Acne Core Outcomes Research Network (ACORN) is an international group of clinicians, researchers, statisticians, patients, journal editors and industry investigators whose objective is to develop a core outcome set for use in acne clinical trials. Following the methodologies outlined by the Harmonizing Outcome Measures in Eczema (HOME) group which included 3 rounds of a Delphi exercise, in 2017 ACORN identified the following core outcome domains: satisfaction with appearance; long-term control of acne, extent of scars and dark marks, satisfaction with treatment received, signs and symptoms of acne, and health-related quality of life.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
This study identified the relevance of three PROMIS domain outcomes in atopic dermatitis, acne, and psoriasis. A PROMIS health assessment, containing computer adaptive tests (CAT) for four domains (Anxiety, Mood, Pain Interference, and Physical Function), was administered on iPads during routine care in three Dermatology clinics at University of Rochester.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Post-inflammatory hyperpigmentation (PIH) is an acquired hypermelanosis that occurs following cutaneous inflammation or injury and often after acne. Therapies targeting oxidative stress and inflammation may hasten PIH resolution. We evaluate treatment efficacy of topical bakuchiol, a botanical with antioxidant and anti-inflammatory properties, on acne-induced PIH. A prospective, single-blinded, non-randomized study was conducted in 20 subjects (phototypes IV-VI) with acne-induced PIH. On day 0, three facial acne papules/pustules were identified.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
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