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Medical News Today: Colorectal cancer: Adding SIRT to chemotherapy boosts survival

For patients with advanced colorectal cancer, new research suggests that adding selective internal radiation therapy to chemotherapy may prolong survival.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Colorectal Cancer Source Type: news

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Abstract Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, is the second leading cause of cancer‐related deaths across the globe. Only a small percentage of HCC patients (~20%‐30%) are diagnosed at an early stage when first‐line treatment options may be effective. The majority of HCC patients (>70%) are diagnosed with unresectable disease and given a poor overall prognosis. Current treatment guidelines recommend locoregional therapy with transarterial chemoembolisation (TACE) and systemic therapy with sorafenib as first‐line treatment for patients with intermediate and advanced stage ...
Source: International Journal of Clinical Practice - Category: Internal Medicine Authors: Tags: REVIEW ARTICLE Source Type: research
Patients with colorectal cancer that has metastasized to the liver derive a significant benefit from selective internal radiation therapy (SIRT) combined with chemotherapy if their primary tumor is a right-sided tumor, but not if it is a left-sided primary tumor.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news
SIRFLOX and FOXFIRE Global findings suggest that adding liver-directed Selective Internal Radiation Therapy (SIRT) to standard first-line chemotherapy may improve overall survival in metastatic colorectal cancer (mCRC) patients with right-sided primary tum... Devices, Oncology Sirtex Medical, SIR-Spheres, Y-90 resin, microspheres, radiotherapy
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
Sirtex Medical (ASX:SRX) said yesterday that the National Comprehensive Cancer Network has recommended the company’s radioactive microspheres in its Clinical Practice Guidelines in Oncology for colon cancer and rectal cancer. The NCCN panel uniformly agreed that selective internal radiation therapy with yttrium-90 microspheres is an option for patients with metastatic, chemotherapy resistant colorectal cancer. The recommendation was supported by the More retrospective analysis study, which included 600 patients with colorectal cancer. The data suggested that selective internal radiation therapy using Y-90 m...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Clinical Trials Drug-Device Combinations Oncology Sirtex Medical Source Type: news
Liver metastases are often the dominant site of metastatic disease in colorectal cancer. Selective internal radiation therapy (SIRT) involves embolising radiolabeled spheres (SIR-Spheres) into the arterial supply of the liver. This review assesses the effectiveness and toxicity of SIRT in the treatment of metastatic colorectal cancer liver metastasis when given alone or with systemic or regional hepatic artery chemotherapy. We reviewed only randomised controlled trials comparing SIRT and chemotherapy (systemic and/or regional) with chemotherapy alone, or comparing SIRT alone with best supportive care.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Source Type: research
ConclusionLonger PFS is associated withKRAS wt vs. mut following SIRT Y90.
Source: Abdominal Imaging - Category: Radiology Source Type: research
New analysis shows patients with metastatic colorectal cancer treated with radiation therapy show better response than those receiving chemotherapy alone.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Radiology / Nuclear Medicine Source Type: news
Authors: Siavashpour Z, Aghamiri MR, Jaberi R, Manshadi HR, Ghaderi R, Kirisits C Abstract PURPOSE: To analyze the optimum organ filling point for organs at risk (OARs) dose in cervical cancer high-dose-rate (HDR) brachytherapy. MATERIAL AND METHODS: In a retrospective study, 32 locally advanced cervical cancer patients (97 insertions) who were treated with 3D conformal external beam radiation therapy (EBRT) and concurrent chemotherapy during 2010-2013 were included. Rotterdam HDR tandem-ovoid applicators were used and computed tomography (CT) scanning was performed after each insertion. The OARs delineation an...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Conclusion The addition of SIRT to FOLFOX-based first-line chemotherapy in patients with liver-dominant or liver-only metastatic colorectal cancer did not improve PFS at any site but significantly delayed disease progression in the liver. The safety profile was as expected and was consistent with previous studies.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Clinical Trials, Radiation, Chemotherapy, Combined Modality, Radiation, Chemotherapy, Combined Modality, Radiation Oncology, Rapid Communications, Interventional Radiology Source Type: research
Abstract The adequate treatment of non-resectable liver metastases from colorectal cancer which are resistant to systemic chemotherapy currently provides a great challenge. The aim is to identify and review key strategies in the treatment of colorectal liver metastases. A search for current literature on the topic of interventional strategies for colorectal metastases was performed in Medline in order of achieves this goal. Studies before 2005 and with less than 20 patients treated for colorectal metastases were excluded. Transarterial chemoembolization (TACE), transarterial embolization (TAE) and selective intern...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
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