Tolerability, persistence and satisfaction. Retrospective cohort study in patients with overactive bladder syndrome treated with transdermal Oxybutynin under Standard ClinicAl pRactice. OSCAR Study.
CONCLUSIONS: The study performed in patients with OAB shows that OXY-TDS provides low incidence of systemic adverse effects, including dry mouth, high persistence, improved adherence rates and high satisfaction of patients after one year of treatment. PMID: 28678009 [PubMed - in process]
New Investor Takeda Ventures Joins Syndicate; Proceeds to Fund Lead Clinical Stage Program for the Treatment of Overactive Bladder and Irritable Bowel Syndrome INDIANAPOLIS and LONDON, Nov. 15, 2017 -- (Healthcare Sales &Marketing Network) -- Outpost ... Biopharmaceuticals, Venture Capital, Personnel Outpost Medicine, Irritable Bowel Syndrome, Overactive Bladder
This study serves as a basis for future studies seeking to maximize the therapeutic efficacy of sensory pudendal nerve stimulation for the symptoms of OAB. PMID: 29141938 [PubMed - as supplied by publisher]
ConclusionsThis NMA suggests that the efficacy of solifenacin 5 mg/day is at least similar to other common antimuscarinics across the spectrum of OAB symptoms analyzed, and is more effective than tolterodine 4 mg/day in reducing incontinence and UUI episodes. Solifenacin 5 mg/day has a lower risk of dry mouth compared with several agents.
Sacral neuromodulation and alterations in brain activity — discussing discrepanciesSacral neuromodulation and alterations in brain activity — discussing discrepancies, Published online: 14 November 2017; doi:10.1038/nrurol.2017.188NatureArticleSnippet(type=standfirst, markup=Sacral neuromodulation is used to treat refractory overactive bladder (OAB). Recent research has shown that changes in brain activity during sacral neuromodulation relate to its mechanism of action and that these changes vary with device settings. Much remains to be discovered about how sacral neuromodulation influences brain activity, but ...
ConclusionsVaginal prolapse repair with MUS reduced the risk of postoperative SUI in women with preoperative SUI symptoms or occult SUI, but serious adverse events were more frequent. Tweetable abstractLess stress incontinence after vaginal prolapse repair with sling, but more adverse events.
ConclusionsWe did not identify differences in the risk of cardiovascular events or mortality among users of individual antimuscarinic OAB drugs.
S. Staley, M. Krall and R. Bologna
D. Robinson, M. Oelke, V. Khullar, H. Wijkstra, R. Tretter, B. Stow, G. Compion and A. Tubaro
Publication date: Available online 11 November 2017 Source:Actas Urológicas Españolas (English Edition) Author(s): A. Alcántara Montero
ConclusionTrigone-including onabotulinumtoxinA injection has superior efficacy to trigone-sparing injection without increased complications. The depth of injection does not influence the efficacy or safety of onabotulinumtoxinA.