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Adult type granulosa cell testicular tumor. Case report and bibliographic review.

CONCLUSION: AGCTT are rare neoplasms with unpredictable behavior. Their metastatic potential has been described, reason why they need a long follow-up; however, they usually have a good prognosis. PMID: 28678014 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

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Source: Ultrasound in Obstetrics and Gynecology - Category: Radiology Authors: Tags: Abstracts Source Type: research
Cyclic AMP (cAMP) is the main intracellular messenger mediating follicle stimulating hormone (FSH) stimulation of aromatase expression in granulosa cells (GCs). An intact PKA pathway in GCs is critical for peak gonadotropin signaling. We have previously shown that AKAP13 is necessary for optimal gonadotropin signaling through cAMP response element binding protein and that both FSH-dependent induction of aromatase and basal aromatase message is decreased with knockdown of AKAP13 in ovaries of AKAP13 conditional knockout mice and in a granulosa cell tumor cell line.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Oral session Source Type: research
ConclusionIn postmenopausal women with new hirsutism that is severe or rapidly progressive, the possibility of an androgen-secreting tumor must be suspected and a thorough evaluation is needed before initiating treatment for idiopathic hirsutism.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Granulosa cell tumors of the ovaries (GCTO), the most common sex cord tumors of the female genitalia, are characterized by a remarkably favorable prognosis but tend to recur even after several years of follow-up. Standard approach to manage these relapsing tumors is almost inexistent and physicians’ choice is most commonly based on his/her personal expertise. Recently, the use of hormone therapy in GCTO has induced prolonged response and survival. In this case report, we report the first successful use of everolimus in the combination of exemestane to reverse the resistance to hormonal therapy with letrozole in a 53-...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Case Reports Source Type: research
This article is protected by copyright. All rights reserved.
Source: Histopathology - Category: Pathology Authors: Tags: Correspondence Source Type: research
Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and funct...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Abstract Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) are bisphenol A (BPA) analogs, where the phenolic moieties are substituted with halogens (Br or Cl). Previous studies indicate that BPA has significant proliferative effects on in vitro cultured epithelial ovarian cancer (EOC) cells. Considering this, we analyzed the effects of both TBBPA and TCBPA at 1, 10, and 50nM on ovarian cancer cell proliferation. The majority of malignant ovarian tumors are epithelial in origin, but approximately 10% are classified as ovarian sex cord tumors, with the most common type being granulosa cell tumors (GCT...
Source: Toxicology in Vitro - Category: Toxicology Authors: Tags: Toxicol In Vitro Source Type: research
Authors: Rinne N, Farthing A, Borley J PMID: 28780898 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
This article is protected by copyright. All rights reserved.
Source: Histopathology - Category: Pathology Authors: Tags: Correspondence Source Type: research
The aim of this study was to explore the clinical utility of microRNAs (miRNAs) as improved markers of ovarian granulosa cell tumours (GCTs) for cancer diagnosis and prognosis prediction. Current histopatholog...
Source: Clinical Epigenetics - Category: Research Authors: Source Type: research
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