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Adult type granulosa cell testicular tumor. Case report and bibliographic review.

CONCLUSION: AGCTT are rare neoplasms with unpredictable behavior. Their metastatic potential has been described, reason why they need a long follow-up; however, they usually have a good prognosis. PMID: 28678014 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

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CONCLUSION: The hemnatological parameters such as MPV, NLR, and platelet count in the detection of malignant ovarian tumors have been evaluated as useful new markers. PMID: 29693870 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
Granulosa cell tumors (GCT) of ovary derive from the ovarian mesenchyme and sex cords and represent 70% of all sex cord-stromal tumors, and 5-8% of all ovarian neoplasms [1 –3].
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Editorial Source Type: research
PMID: 29665458 [PubMed - as supplied by publisher]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research
Abstract Chemerin is an adipocyte-secreted protein that associates with obesity, inflammation, metabolic dysfunction, and carcinogenesis. Previous studies have shown human granulosa cells to produce bioactive chemerin and its receptor CMKLR1. In the present study, we demonstrated that the mRNA level of chemerin receptor is higher in a granulosa cell tumor cell line than in epithelial cancer cells, whereas chemerin expression and secretion were lower. Various exogenous factors, such as bisphenol A and its halogenated derivatives tetrabromobisphenol A and tetrachlorobisphenol A, can affect adipokine expression. For ...
Source: Toxicology Letters - Category: Toxicology Authors: Tags: Toxicol Lett Source Type: research
A 12-year-old, female mangrove snake (Boiga dendrophila melanota) was presented with a one-month history of anorexia, lethargy, and progressive distention of the caudal coelomic cavity. Based on ultrasonographic and cytological examination, an ovarian neoplasia was considered to be the presumptive antemortem diagnosis. Histological examination confirmed the diagnosis of a granulosa cell tumor (GCT) with metastatic tumors in the coelomic fat bodies. Four months following oophorectomy and surgical removal of the distant metastasis, the snake was euthanized because of acute onset of lethargy, cardiomegaly, and dyspnea.
Source: Journal of Exotic Pet Medicine - Category: Veterinary Research Authors: Tags: Case Report Source Type: research
Conclusions Younger age, smaller tumor size, early stage, and GCT histologic type are independent prognostic factors for improved survival in patients with malignant SCST with lymphadenectomy. Stratified LODDS could be regarded as an effective value to assess the lymph node status, and to predict the survival status of patients.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
A 12-year-old, female mangrove snake (Boiga dendrophila melanota) was presented with a one-month history of anorexia, lethargy, and progressive distention of the caudal coelomic cavity. Based on ultrasonographic and cytological examination, an ovarian neoplasia was considered to be the presumptive antemortem diagnosis. Histological examination confirmed the diagnosis of a granulosa cell tumor (GCT) with metastatic tumors in the coelomic fat bodies. Four months following oophorectomy and surgical removal of the distant metastasis, the snake was euthanized because of acute onset of lethargy, cardiomegaly, and dyspnea.
Source: Journal of Exotic Pet Medicine - Category: Veterinary Research Authors: Tags: Case Report Source Type: research
AbstractThe expression of adiponectin receptors AdipoR1 and AdipoR2 has been reported in the human ovary and ovarian cancer tissues. Moreover, adiponectin has been reported to act as an anti-tumor factor by inhibiting cancer cell proliferation. Thus, we investigate whether adiponectin and its receptors influence ovarian cancer development. In the present study, we found that adiponectin was not expressed in the granulosa cell line (COV434), and epithelial ovarian cancer cell lines (OVCAR-3, SKOV-3, and Caov-3). Additionally, we found that AdipoR1 and AdipoR2 expression is lower in epithelial ovarian cancer cells than in gr...
Source: Hormones and Cancer - Category: Cancer & Oncology Source Type: research
Tight junctions (TJ) are protein structures that control the transport of water, ions and macromolecules across cell layers. Functions of the transmembrane TJ protein, occluding (OCLN) and the cytoplasmic TJ proteins, tight junction protein 1 (TJP1; also known as zona occludens protein-1), cingulin (CGN) and claudins (CLDN) are reviewed, and current evidence of their role in the ovarian function is reviewed. Abundance of OCLN, CLDNs and TJP1 mRNA changed during follicular growth. In vitro treatment with various growth factors known to affect ovarian folliculogenesis indicated that CGN, OCLN and TJP1 are hormonally regulate...
Source: Reproduction - Category: Reproduction Medicine Authors: Tags: Reviews Source Type: research
Condition:   Ovarian Cancer Intervention:   Drug: Enzalutamide 40 MG Sponsor:   Grupo Español de Tumores Huérfanos e Infrecuentes Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Granulosa Cell Tumor | Ovaries | Study | Ultrasound | Urology & Nephrology