Adult type granulosa cell testicular tumor. Case report and bibliographic review.
CONCLUSION: AGCTT are rare neoplasms with unpredictable behavior. Their metastatic potential has been described, reason why they need a long follow-up; however, they usually have a good prognosis. PMID: 28678014 [PubMed - in process]
Summary Postmenopausal hyperandrogenism can be tumour‐ or non‐tumour‐related, with pathology residing either in the ovary or adrenal gland(s). The tempo of investigation is determined by the clinical severity of hyperandrogenism (presence/absence of actual virilisation) and degree of serum testosterone elevation. When clinical or biochemical hyperandrogenism is severe, rapidly developing, or associated with hypercortisolism, screening for adrenocortical or ovarian carcinoma with cross‐sectional imaging should be prioritised over detailed biochemical evaluation. Adrenal hyperandrogenism is readily characterised, bot...
Recently, anti-M üllerian hormone (AMH) has been reported as a useful diagnostic marker for equine granulosa-cell tumors (GCT). The aim of this study was to examine and compare serum AMH and immunoreactive (ir)-inhibin concentrations in mares with ovarian abnormalities other than GCT compared to mares with known GC T in order to determine more useful diagnostic criteria. Mares with a possible GCT based upon history were subsequently classified into those with GCT confirmed by histopathology and mares with other ovarian abnormalities (AO) without a GCT based on follow-up fertility information.
CONCLUSIONS: Recognition of the distinct genetic basis for a group of these tumors improves precise classification in difficult cases and promotes mutation-based screening and early detection. PMID: 29037807 [PubMed - as supplied by publisher]
Ovarian sex-cord stromal tumors that have between 10% and 50% granulosa cells in a prominent fibrothecomatous background have been referred to as granulosa theca cell tumors or mixed granulosa theca cell tumors. The classification and prognosis of these tumors is not clear. Most adult granulosa cell tumors of the ovary harbor a mutation in the FOXL2 gene, whereas fibromas and thecomas lack this mutation. The aim of our study was to assess the FOXL2 mutation status of ovarian granulosa theca cell tumors and to correlate the mutation status with morphologic and clinical characteristics. A FOXL2 mutation was detected in 6 of ...
Conclusion Lymph node metastasis in initially staged AGCT is rare. Routine pelvic and paraaortic lymph node dissection may be omitted in these patients.
A 6-month-old girl presented to our institution with intermittent vaginal bleeding for two months. After careful examination, neither trauma nor foreign body was noted. Laboratory examination revealed an elevated serum level of estradiol (669 pg/ml) associated with very low serum levels of follicular stimulating hormone and luteinizing hormone. Both pelvic ultrasound and magnetic resonance image showed a well-encapsulated mass lesion at right adnexa, measured 4.0 × 5.4 cm in size, containing mainly soft tissue with cystic component .
Cyclic AMP (cAMP) is the main intracellular messenger mediating follicle stimulating hormone (FSH) stimulation of aromatase expression in granulosa cells (GCs). An intact PKA pathway in GCs is critical for peak gonadotropin signaling. We have previously shown that AKAP13 is necessary for optimal gonadotropin signaling through cAMP response element binding protein and that both FSH-dependent induction of aromatase and basal aromatase message is decreased with knockdown of AKAP13 in ovaries of AKAP13 conditional knockout mice and in a granulosa cell tumor cell line.
ConclusionIn postmenopausal women with new hirsutism that is severe or rapidly progressive, the possibility of an androgen-secreting tumor must be suspected and a thorough evaluation is needed before initiating treatment for idiopathic hirsutism.