Three new alkaloids and a new iridoid glycoside from the roots of Rehmannia glutinosa

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): Meng Li, Xiaolan Wang, Zhiguang Zhang, Jingke Zhang, Xuan Zhao, Xiaoke Zheng, Weisheng Feng Three new alkaloids, rehmanalkaloid A-C (1-3), and a new iridoid glycoside, rehmaglutoside L (4), together with nine known compounds, including (8S)-7,8-dihydrogeniposid (5), diglycoside (6), monomelittoside (7), mussaenoside (8), darendoside A (9), syringing (10), phenyl-6-O-β-d-xylopyranosyl-O-β-d-glucopyranoside (11), (7R, 8S)-4,9-dihydroxy-3,3′-dimethoxy-7,8-dihydrobenzofuran-1′-propanalneolignan (12), and trans-liovil (13), were isolated from a 95% EtOH extract of dried roots from Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI–MS, and 1D and 2D NMR) analyses. Additionally, compounds 4-8 (iridoid glycosides) were evaluated for their protective effects on H714444444444444444444466666666669c2 cardiocytes impaired by doxorubicin. Among them, compounds 4-8 exhibited protective effects against DOX-induced cardiotoxicity. Graphical abstract

Source: Phytochemistry Letters - July 6, 2017 Category: Chemistry Source Type: research