Gut Microbiota in Health, Diverticular Disease, Irritable Bowel Syndrome, and Inflammatory Bowel Diseases: Time for Microbial Marker of Gastrointestinal Disorders?

Few data exist on differences in gut microbiota composition among principal gastrointestinal (GI) diseases. We evaluated the differences in gut microbiota composition among uncomplicated diverticular disease (DD), irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) patients. DD, IBS, and IBD patients along with healthy controls (CT) were enrolled in our Italian GI outpatient clinic. Stool samples were collected. Microbiota composition was evaluated through a metagenomic gene-targeted approach. GI pathology represented a continuous spectrum of diseases where IBD displayed one extreme, while CT displayed the other. Among Phyla, Biplot PC2/PC3 and dendogram plot showed major differences in samples from IBS and IBD. DD resembled species CT composition, but not forBacteroides fragilis. In IBS,Dialister spp. and thenFaecalibacterium prausnitzii were the most representative species. Ulcerative colitis showed a reduced concentration ofClostridium difficile and an increase ofBacteroides fragilis. In Crohn's disease,Parabacteroides distasonis was the most represented, whileFaecalibacterium prausnitzii andBacteroides fragilis were significantly reduced. Each disorder has its definite overall microbial signature, which produces a clear differentiation from the others. On the other hand, shared alterations constitute the “core dysbiosis” of GI diseases. The assessment of these microbial markers represents a parameter that may complete the diagnostic assessment...
Source: Digestive Diseases - Category: Gastroenterology Source Type: research

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Conclusions: Recurrent CA-CDI in children in our population is less common than previously reported. This study supports first-line treatment with the standard, short course metronidazole in most cases of primary CA-CDI.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Publication date: Available online 16 October 2019Source: Food ChemistryAuthor(s): Cinzia Ingallina, Donatella Capitani, Luisa Mannina, Simone Carradori, Marcello Locatelli, Antonella Di Sotto, Silvia Di Giacomo, Chiara Toniolo, Gabriella Pasqua, Alessio Valletta, Giovanna Simonetti, Alessia Parroni, Marzia Beccaccioli, Giuliana Vinci, Mattia Rapa, Anna Maria Giusti, Caterina Fraschetti, Antonello Filippi, Alessandro Maccelli, Maria Elisa CrestoniAbstractCelery is a widely used vegetable known for peculiar sensorial and nutritional properties. Here, the white celery (Apium graveolens L.) “sedano bianco di Sperlonga&r...
Source: Food Chemistry - Category: Food Science Source Type: research
The objectives of this article are to review key aspects of the epidemiology of T. callipaeda, summarise animal and human cases in Europe and emphasise the importance of education and awareness among veterinarians, physicians (particularly ophthalmologists) and animal, in order to owners to tackle this zoonosis.Graphical abstract
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Publication date: Available online 17 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Francesco Grandoni, Francesco Napolitano, Maria Carmela Scatà, Giovanna De MatteisAbstractCluster of differentiation 4 (CD4) is the accessory protein non-covalently bounded to T cell receptor (TCR) that recognize an invariant region of MHC class II on antigen presenting cell (APC). Its cytoplasmic tail, physically associated with a protein tyrosine kinase, is important in the activation of helper/inducer T (TH) lymphocytes. The anti-bovine CD4 monoclonal antibody (mAb) CC8 is a clone usefully used in flow cy...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Publication date: Available online 18 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): I.A.M. van Thiel, S. Botschuijver, W.J. de Jonge, J. SeppenAbstractVisceral pain, characterized by abdominal discomfort, originates from organs in the abdominal cavity and is a characteristic symptom in patients suffering from irritable bowel syndrome, vulvodynia or interstitial cystitis. Most organs in which visceral pain originates are in contact with the external milieu and continuously exposed to microbes. In order to maintain homeostasis and prevent infections, the immune- and nervous sy...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Conclusionsanti-TG6 do not seem to be associated to epilepsies with cerebral calcifications.
Source: Seizure - Category: Neurology Source Type: research
In conclusion, the current survey suggests that Abincol® may be considered an effective and safe therapeutic option in the management of patients with chronic intestinal disorders. PMID: 31292420 [PubMed - in process]
Source: Acta Bio-Medica : Atenei Parmensis - Category: General Medicine Authors: Tags: Acta Biomed Source Type: research
By just engaging in the basic strategies in the Wheat Belly Total Health, Wheat Belly 10-Day Grain Detox, or Undoctored programs, many mild cases of small intestinal bacterial overgrowth, SIBO, reverse. These efforts thereby restore your ability to ingest prebiotic fibers without diarrhea, bloating, gas, abdominal discomfort, joint pain, and dark emotional feelings. Many people thereby are relieved of irritable bowel syndrome symptoms, fibromyalgia, or restless leg syndrome, or have greater power in reversing autoimmune conditions such as rheumatoid arthritis. Unfortunately, not everybody enjoys reversal of SIBO with our b...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: SIBO grain-free probiotic undoctored wheat belly Source Type: blogs
Conclusions As the intestinal mucosa surface constitutes the major surface of the body which is in direct contact with the outer environment, intestinal immune homeostasis must be accurately regulated. The interplay between commensal microbiota, intestinal stromal cells, and the mucosal immune system components should guarantee the intestinal homeostasis to avoid a sustained inflammation that could induce tissue damage. However, several factors can lead to inflammation through homeostasis breakdown. Figure 1 summarizes the main points that have been reviewed here. We have described what it is known so far about the role o...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Join us Tuesday evening, March 12th, at 8 pm EST/ 7 pm CST/6 pm MT/5 pm PT for my Undoctored SIBO Workshop: A 2-hour in-depth exploration of SIBO that I shall present via live video broadcast. The cost to attend is $55. An unprecedented number of people now have small intestinal bacterial overgrowth, SIBO, an intestinal condition that has reached epidemic proportions. SIBO causes or worsens numerous health conditions such as fibromyalgia, irritable bowel syndrome, ulcerative colitis, restless leg syndrome, ulcerative colitis and Crohn’s disease. If you have any of these conditions or have diabetes (typ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
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