Here ’s something completely different for low back pain

Follow me on Twitter @RobShmerling It’s a question that has challenged generations of patients and their doctors. The answer has changed over the years. When I was in medical school in the early 1980s, bedrest for a week or more was often recommended for severe back pain. This sometimes included hospital admission. Then, research demonstrated that prolonged bedrest was actually a bad idea. It was no better (and often worse) than taking it easy for a day or two followed by slowly increasing activity, including stretching and strengthening the back. Medications, including pain relievers, non-steroidal anti-inflammatory drugs (NSAIDs), and muscle relaxants were a standard part of the initial treatment of back pain. But, recommendations released in February 2017 urge doctors to change their approach to back pain once again. Didn’t I just hear that NSAIDs don’t work well for back pain? You did. A recent study found that NSAIDs did not work well for back pain. But, new recommendations take that conclusion even further: it may be best to avoid medications altogether — at least at the start. The American College of Physicians has just come out with new guidelines for the treatment of low back pain based on a review of more than 150 studies. The big news? Medications tend to have only temporary and modest benefits, so it makes sense to try something other than a pill. The specifics depend on the type and duration of back pain. For new low back pain (lasting les...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Back Pain Complementary and alternative medicine Health Injuries Pain Management Source Type: blogs

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Publication date: September 2018Source: Nano Energy, Volume 51Author(s): Jun Li, Lei Kang, Yanhao Yu, Yin Long, Justin J. Jeffery, Weibo Cai, Xudong WangAbstractImplantable nanogenerator (i-NG) has shown great promises for enabling self-powered implantable medical devices (IMDs). One essential requirement for practical i-NG applications is its long-term bio-compatibility and bio-safety. This paper presents a systematic study of polydimethylsiloxane (PDMS) and PDMS/Parylene-C packaged polyvinylidene fluoride (PVDF) NGs implanted inside female ICR (Institute of Cancer Research) mice for up to six months. The PVDF NG had a st...
Source: Nano Energy - Category: Nanotechnology Source Type: research
Publication date: Available online 21 July 2018Source: Seminars in Cell &Developmental BiologyAuthor(s): Jiayun Hou, Xiangdong WangAbstractPolycomb group proteins (PcG) play important roles in the maintenance of DNA sequencing and multi-dimensional organization of genome. The main PcG complexes are consisted of Polycomb repressive complex 1 and 2, of which the diversity is dependent upon target gene sequences and functions. The present review initially explores the mechanism-based relationship and functional roles of PcG proteins in the interplay between epithelial mesenchymal transition (EMT) and chromatin dynamics in...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
In this study, we found that overexpression of nicotinamide nucleotide transhydrogenase (NNT) was associated with shorter overall and disease free survival in gastric cancer. The NNT is considered a key antioxidative enzyme based on its ability to regenerate NADPH from NADH. Knockdown of NNT caused significantly NADPH reduction, induced high levels of ROS and significant cell apoptosis under oxidative stress conditions such as glucose deprival and anoikis. In vivo experiments showed that NNT promoted tumor growth, lung metastasis and peritoneal dissemination of gastric cancer. Moreover, intratumoral injection of NNT siRNA ...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 21 July 2018Source: Chemico-Biological InteractionsAuthor(s): Bharath Kumar VelmuruganAbstractThe psychoactive properties of cannabinoids are well known and there has been a continuous controversy regarding the usage of these compounds for therapeutic purposes all over the world. Their use for medical and research purposes are restricted in various countries. However, their utility as medications should not be overshadowed by their negative physiological activities. This review article is focused on the therapeutic potential and applications of phytocannabinoids and endocannabinoids. It h...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: September 2018Source: Journal of Science and Medicine in Sport, Volume 21, Issue 9Author(s): R. Johnston, R. Cahalan, M. O’Keeffe, K. O’Sullivan, T. ComynsAbstractObjectivesTo determine the associations between training load, baseline characteristics (e.g. age or previous injury) and rate of musculoskeletal injury and/or pain specifically within an Endurance Sporting Population (ESP).DesignProspectively registered systematic review.MethodsEight electronic databases were searched by two independent reviewers. Studies were required to prospectively monitor both (i) training loads and (ii) muscul...
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
ConclusionsImpingement-type bony morphology was related to cartilage defects, but not labral tear. Hip pain was not associated with pathology or bony morphology. Longitudinal studies are warranted to determine if bony features, such as cam morphology, acetabular retroversion or anteversion, are precursors to symptomatic hip joint injury or osteoarthritis.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
In this month ’s first feature article, Silva’s group report that a 16 week in-classroom standing desk intervention reduced sitting time without an increase in sedentary behaviour out of school time. In the second featured article, Tsikopoulos and colleagues report the results of a network meta-analysis on in terventions to enhance dynamic balance in individuals with chronic ankle instability. In the third feature article Mayes, Smith and Cook suggest that impingement related bony morphology is not related to pain in professional dancers’ hips.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Authors: Tags: Editorial Source Type: research
Publication date: Available online 21 July 2018Source: International Journal of Nursing SciencesAuthor(s): Dalia Salah El-Deen, Naglaa F.A. YoussefAbstractObjectiveTo investigate the effect of cryotherapy application before versus after subcutaneous anticoagulant injection (SCAI) on pain intensity and hematoma formation.MethodsA quasi-experimental design was utilized. A convenient sample of 105 adult patients, who were admitted to one of the biggest teaching hospitals in Cairo and receiving SCAI, were recruited over a period of six months. Patients were randomly allocated into three groups: A Control group who received the...
Source: International Journal of Nursing Sciences - Category: Nursing Source Type: research
Conclusion: Overall, the results of this study suggested the potential beneficial effects of the extract mixture for use as complementary medicine alongside conventional treatment of metformin. The extract mixture contained many highly potent compounds for treating T2DM and preventing short- and long-term risk complications of diabetes.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
BOWEL cancer symptoms include stomach pain, a change in bowel habits, and finding blood in your stool. You could reveal your risk of cancer by thinking about how often you use the toilet. How many toilet trips counts as a ‘normal’ amount?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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