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Deadly dengue fever outbreak kills hundreds in Sri Lanka

A deadly outbreak of dengue fever has ravaged the island nation of Sri Lanka, killing at least 227 people and infecting tens of thousands.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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The recent outbreak of Zika virus (ZIKV) in the Americas has challenged diagnostic laboratory testing strategies. At the Wadsworth Center, ZIKV serological testing was performed for over 10,000 specimens, using a combination of an enzyme-linked immunosorbent assay (ELISA) for IgM antibodies (Abs) to ZIKV, a polyvalent microsphere immunoassay (MIA) to detect Abs broadly reactive with flaviviruses, and a plaque reduction neutralization test (PRNT) for further testing. Overall, 42% of patients showed serological evidence of flavivirus infection (primarily past dengue virus [DENV] infection), while 7% possessed IgM Abs to ZIKV...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Virology Source Type: research
DiscussionThe aims of the trial are to simultaneously evaluate the efficacy of an innovative dengue vector control intervention and developing predictive dengue models. Assessment of human exposure to mosquito bites by detecting antibodies generated againstAedes saliva proteins in human blood samples has, so far, not been applied in dengue epidemiological risk assessment and disease surveillance methodologies. Likewise, DENV detection in mosquitoes (adult and immature stages) has not been used in any practical way for routine disease surveillance strategies. The integration of multiple outcome measures will assist health a...
Source: Trials - Category: Research Source Type: clinical trials
Authors: Flahault A, de Castaneda RR, Bolon I Abstract Global changes are major determinants for infectious diseases, although attributable, part of climate change remains debatable. Vector-borne diseases are prone to be impacted by global warming, although other factors may play a substantial role, evidenced by the dramatic decrease in malaria in the last decades in places where climate change has deep and significant effects. There is now evidence that in some areas of the world, e.g. Horn of Africa, warm El Niño Southern Oscillations (ENSO), which are observed in the South Pacific Ocean, are associated wi...
Source: Public Health Reviews - Category: International Medicine & Public Health Tags: Public Health Rev Source Type: research
Abstract Being the largest archipelago country in the world, with a tropical climate and a unique flora and fauna, Indonesia habitats one of the most diverse biome in the world. These characteristics make Indonesia a popular travel destination, with tourism numbers increasing yearly. These characteristics also facilitate the transmission of zoonosis and provide ideal living and breading circumstances for arthropods, known vectors for viral diseases. A review of the past 10 years of literature, reports of the Ministry of Health, Republic of Indonesia and ProMED-mail shows a significant increase in dengue infection ...
Source: Critical Reviews in Microbiology - Category: Microbiology Authors: Tags: Crit Rev Microbiol Source Type: research
Conclusion: Although the tempe rature does not statistically display an association with recorded cases of dengue, we were able to verify that temperature peaks coincide with dengue outbreak peaks. Future studies on environmental pollution and its influence on the development of Aedes aegypti mosquito during all stages of its lif e cycle, and the definition of strategies for better monitoring, including campaigns and surveillance, would be compelling.Resumo Objetivo: As altera ções globais que têm ocorrido interferem no ambiente natural, influenciando diretamente no crescimento da transmissão de ...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
This study accessed the patients information on demographic characteristics, physical signs and symptoms. Study population This is a cross-sectional and observational study carried out in Brazil during DENV and ZIKV epidemic occurred in 2016. Patients were assisted at the Healthy Unit UPA Coronel Antonino in Campo Grande, MS, Brazil from February to March of 2016. During the study 134 suspected arboviral infection cases were included and submitted to investigation. Patients presenting fever, rash during acute phase of infection (up to the 7th day after disease onset) followed by at least two of the following signals a...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
ConclusionsZika virus is associated with a wide range of neurological manifestations, including central nervous system disease. Chikungunya virus appears to have an equally important association with neurological disease in Brazil, and many patients had dual infection. To understand fully the burden of Zika we must look beyond GBS, and also investigate for other co-circulating arboviruses, particularly chikungunya.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
CONCLUSION: the methodology adopted enabled qualified training of students to cope with dengue. PMID: 29412306 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
Zika virus is a flavivirus that is spread by the bite of infected Aedes mosquitoes. The current outbreak and swift dissemination/spread of Zika virus (ZIKV) and its linkage to birth defects and neurological syndromes has prompted the development of novel diagnostic tests. Because ZIKV is serologically similar to other flaviviruses such as dengue virus (DNV), cross-reactivity occurs in diagnostic tests and can result in misdiagnoses. This is especially evident in populations that live in dengue-endemic regions or have received heterologous flaviviral vaccines (i.e., yellow fever 17D). CDC researchers have developed seven mo...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
ConclusionsThe Forum concluded that the evidence collected can inform policy decisions, but also that important research gaps have yet to be filled.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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