June ’s top stories: NIH’s Phase I/II trial for chikungunya, Boehringer & Eli Lilly ’s empagliflozin trial

A new Phase I/II clinical trial of MV-CHIKV for the prevention of the chikungunya virus began enrolment, while Boehringer Ingelheim, along with Eli Lilly and Company, made plans to evaluate empagliflozin in a new clinical outcomes trial for chronic k …
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

Related Links:

What potential value could big data bring to the field of public health? In this case, it helps to provide insight into chikungunya outbreaks in Europe.Emerging Infectious Diseases
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
Abstract Chikungunya virus (CHIKV) a re-emerging mosquito-borne alpha virus causes significant distress which is further accentuated in the lack of specific therapeutics or a preventive vaccine, mandating accelerated research for anti-CHIKV therapeutics. In recent years, drug repositioning has gained recognition for the curative interventions for its cost and time efficacy. CHIKV envelope proteins are considered to be the promising targets for drug discovery because of their essential role in viral attachment and entry in the host cells. In the current study, we propose structure-based virtual screening of drug mo...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
In this study, we estimate the direct medical costs, cost of lost wages due to absenteeism, and years lived with disability (YLD) associated with the 2014–2015 CHIKV outbreak in the U.S. Virgin Islands (USVI). For this analysis, we used surveillance data from the USVI Department of Health, medical cost data from three public hospitals in USVI, and data from two studies of laboratory-positive cases up to 12 months post illness. On average, employed case-patients missed 9 days of work in the 12 months following their disease onset, which resulted in an estimated cost of $15.5 million. Estimated direct healthcare costs ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
[The Conversation Africa] Leishmaniasis ranks on the World Health Organisation's list of neglected tropical diseases, along with the usual suspects such as dengue, chikungunya and rabies.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Radio Dabanga] Jabeit -Sudanese medical sources have reported an outbreak of the mosquito-borne chikungunya fever in Jebeit in Red Sea state.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
WEDNESDAY, July 17, 2019 -- Some mosquitoes spread diseases to humans through their bite, passing along harmful pathogens like Zika, dengue fever, West Nile virus and chikungunya. Now humans are turning the tables, infecting these dangerous...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
The number of biting Asian tiger mosquitoes, which spread dengue and Chikungunya, has been reduced by more than 80 per cent at two sites in Guangzhou, China
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
The present study shows that the most prominent human arboviruses worldwide (dengue viruses 1, 2, 3, and 4, Chikungunya virus, and Zika virus) can infect wild animals and jump from urban to sylvatic maintenance cycles in South America, as did the yellow fever virus in the past. All these viruses are transmitted by the anthropophilic mosquito Aedes aegypti and cause epidemics throughout Brazil. The yellow fever virus is the oldest example of an urban arbovirus that became sylvatic in South America. Currently, the disease is a zoonosis of non-human primates that moves like a wave through forests of the Brazilian countryside,...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Abstract The mosquito-borne Chikungunya virus (CHIKV) causes acute pain and joint inflammation, and in recent years, the virus has caused large epidemics in previously CHIKV-free geographic areas. To advance the understanding of host factors that antagonize CHIKV, we show that synthetic agonist of Liver X Receptor (LXR-623) inhibits CHIKV replication by upregulating the cholesterol exporter ABCA1, and that endogenous and pharmacological activation of interferon signaling pathway partners with LXR-623 to generate a superior antiviral state. PMID: 31307983 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
bel Arthropod-borne viruses (arboviruses) of vertebrates including dengue, zika, chikungunya, Rift Valley fever, and blue tongue viruses cause extensive morbidity and mortality in humans, agricultural animals, and wildlife across the globe. As obligate intercellular pathogens, arboviruses must be well adapted to the cellular and molecular environment of both their arthropod (invertebrate) and vertebrate hosts, which are vastly different due to hundreds of millions of years of separate evolution. Here we discuss the comparative pressures on arbovirus RNA genomes as a result of a dual host life cycle, focusing on pressur...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
More News: Chikungunya | Clinical Trials | Empagliflozin | Jardiance | Pharmaceuticals