Homeopathic potencies of Arnica montana L. change gene expression in a Tamm-Horsfall protein-1 cell line in vitro model: the role of ethanol as a possible confounder and statistical bias

Publication date: July 2017 Source:Journal of Integrative Medicine, Volume 15, Issue 4 Author(s): Salvatore Chirumbolo, Geir Bjørklund Marzotto et al. showed that homeopathic preparations of Arnica montana L. acted directly on gene expression of Tamm-Horsfall protein-1 (THP-1) monocyte/macrophage cell lines activated with phorbol12-myristate13-acetate and interleukin-4 (IL-4). A. montana homeopathic dilutions are used in complementary and alternative medicine to treat inflammation disorders and post-traumatic events as well as for wound repair. The French Pharmacopoeia of these remedies uses 0.3% ethanol in each centesimal dilution. In this paper, we discuss how ethanol-containing A. montana homeopathic centesimal dilutions can change gene expression in IL-4-treated monocyte/macrophage THP-1. We assessed the role of ethanol in the Arnica homeopathic dilutions containing this alcohol by investigating its action on gene expression of THP-1 cell. Evidence would strongly suggest that the presence of ethanol in these remedies might play a fundamental role in the dilutions ability to affect gene expression, particularly for doses from 5c to 15c. Where, rather than playing a major role in the mesoscopic structure of water, the ethanol might have a chemical-physical role in the induction of THP-1 gene expression, apoptosis, and deoxyribonucleic acid function. This evidence generates a debate about the suggestion that the use of a binary-mixed solvent in homeopathic chemistry,...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research

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June isPTSD Awareness Month. Posttraumatic Stress Disorder (PTSD) can occur inchildren and adults who've experienced or witnessed a traumatic event. This can include a natural disaster, accident, physical/sexual/emotional abuse, terrorist act, war/combat, rape or other types of violent personal assaults.Post Traumatic Stress Disorder is a treatable mental health disorder. Symptoms of PTSDIntrusive memories: Upsetting dreams or reoccurring flashbacks about the event.Avoidance: Avoiding the memory of the event, or places and people that remind you of the event.Negative changes in thinking or mood: Feeling numb...
Source: Dr. Deborah Serani - Category: Psychiatry & Psychology Tags: awareness campaigns PTSD. Source Type: blogs
Authors: Langer KG Abstract Memory and forgetfulness have been viewed since antiquity from perspectives of physical, emotional, and spiritual states of well-being, and conceptualized philosophically. Numerous discussions of memory loss, or case reports, existed, but a fundamental advance in conceptualization of memory loss as a pathological clinical phenomenon originated when Sauvages classified "amnesia" as a medical disorder, in 1763. Originally, amnesia was recognized as a weakening or dissolution of memory, according to a taxonomy that ascribed known causes to the disorder. Etiologic factors included ...
Source: Frontiers of Neurology and Neuroscience - Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research
ConclusionsMusculoskeletal problems are the main occupational health problems experienced by the study group. New findings include a low but important prevalence of ultraviolet radiation–associated conditions. One in 3 guides have experienced significant psychological trauma, and one quarter of these had symptoms of PTSD.
Source: Wilderness and Environmental Medicine - Category: Environmental Health Source Type: research
In conclusion, FT and its interplay with personality traits commonly related to disorganized attachment (anxiety and PTSD) might be important factors to consider within therapeutic programs for persons with substance addiction.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
It’s believed that over half of women (51%) and one out of every eight men will experience at least one attempted or completed sexual assault in their lifetime. One out of every four women and 8% of men will experience intimate partner violence in their lifetime. Fifty to 80% of these survivors will know their attacker. Sexual assault isn’t a crime of dark alleys and masked strangers, but one that’s underrepresented in the public conscience and routinely minimized by the layperson and healthcare providers alike.1,2,3 Statistics show a system skewed towards perpetrators; for every 100 assaults that are rep...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Trauma Exclusive Articles Source Type: news
Background: The mutual maintenance model proposes that post-traumatic stress disorder (PTSD) symptoms and chronic physical symptoms have a bi-directional temporal relationship. Despite widespread support for this model, there are relatively few empi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Today's case is that of a 26-year-old man who was transferred to the emergency department (ED) by ambulance from the scene of a fall from a fourth-story window. The patient had been drinking alcohol that evening and the fall was witnessed, however, no a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Publication date: September 2019Source: Biomedicine &Pharmacotherapy, Volume 117Author(s): Jan Aaseth, Grethe Emilie Roer, Lars Lien, Geir BjørklundAbstractRecent research strongly supports the hypothesis that posttraumatic stress disorder (PTSD) can be accompanied by obesity and related metabolic disturbances. The mechanisms of these associations are however still not well defined, although disturbed functions in the sympathetic-adrenergic nervous system together with the disturbed release of hormones via the endocrine HPA (hypothalamic-pituitary-adrenal) axis apparently play a role. Leptin resistance and ghrel...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
und G Abstract Recent research strongly supports the hypothesis that posttraumatic stress disorder (PTSD) can be accompanied by obesity and related metabolic disturbances. The mechanisms of these associations are however still not well defined, although disturbed functions in the sympathetic-adrenergic nervous system together with the disturbed release of hormones via the endocrine HPA (hypothalamic-pituitary-adrenal) axis apparently play a role. Leptin resistance and ghrelin excesses might contribute to a disturbed hypothalamic function, and also disturb other cerebral functions, leading to dysfunctional reward s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Authors: Ostergaard M, Seitz R, Jatzkowski L, Speidel S, Höcker W, Odenwald M Abstract Objective: There is a lack of empirical knowledge on how different comorbid disorders and symptoms change in the course of initial abstinence and withdrawal. The aim of this study is to replicate previous findings on the symptom course using a larger sample and up-to-date psychometric instruments. Methods: During inpatient alcohol detoxification, we measured comorbid depression (Beck Depression Inventory second revision; BDI-II) and posttraumatic stress disorder (PTSD Checklist for DSM-5; PCL-5) symptoms twice among 87 parti...
Source: Journal of Dual Diagnosis - Category: Addiction Tags: J Dual Diagn Source Type: research
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