First detection of Escherichia coli harboring mcr-1 gene from retail domestic chicken meat in Japan.

We report here the first detection of mcr-1 from retail chicken meats. A total of 70 ESBL-producing E. coli isolates recovered from retail chicken meats collected between August 2015 and June 2016 were screened for mcr-1, which resulted in positive for one isolate of CTX-M-1 producing E. coli belonging to ST1684, phylogroup A. The mcr-1 was not located in an IncI1 plasmid encoding a blaCTX-M-1. However, whole plasmid sequencing revealed that mcr-1 was located on an IncI2 plasmid. Sequences of nikB-mcr-1-pap2-ydfA-topB region were mostly identical to those of previously described IncI2 plasmid pECJS-61-63 harbored by E. coli from pig feces in China except for containing a synonymous mutation in mcr-1 gene of this study. The mcr-1-encoding plasmids have not yet been identified in human isolates in Japan. Thus, strict monitoring or surveillance of colistin resistance among Gram-negative bacteria recovered from retail meat, food animals under colistin pressure, and human are crucial to assess their current prevalence status. PMID: 28674313 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
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Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
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