Candida tropicalis Biofilm Formation and Efficacy of Liposomal Amphotericin B using time-lapse images.

This study was conducted to investigate the process of biofilm formation by C. tropicalis and the antifungal activity of liposomal amphotericin B (LAB) against both forming-biofilms and developed-biofilms using time-lapse imaging. We found that C. tropicalis has high ability of hyphae growth and gas generation due to high metabolic activity. Thus, we visually observed that C. tropicalis formed aggressive biofilms which are fast-growing type. Also, LAB acts immediately and completely inhibits against forming-biofilms. Furthermore, we demonstrated that LAB was effective against developed-biofilms of C. tropicalis by reducing the growth of hyphae and their morphology changes. The results suggest that LAB may be effective for treatment of infections caused by catheter-related C. tropicalis biofilms. PMID: 28674314 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research