Management of Lyme Disease in European Children: a Review for Practical Purpose

AbstractPurpose of ReviewLyme disease is a tick-borne zoonosis transmitted through a bite of a tick carrying a spirochete belonging toBorrelia species. In the last 20  years, the reported incidence of Lyme disease is increased by three times in Europe. Clinically, the illness develops through a primary stage with a typical skin rash (erythema marginatum), then a secondary stage with possible neurologic or cardiac involvement. The last stage (chronic Lyme disease ) is mainly represented by arthritis or late neurological complications but nowadays is rarely seen due to precocious antibiotic use.Recent FindingsThe diagnosis of Lyme disease is essentially based on history in agreement with tick exposure (living/recent traveling in endemic area or tick bite) and clinical findings compatible with the disease. At present, no laboratory diagnostic tool available can neither establish nor exclude the diagnosis of Lyme disease. The management of Lyme disease should comprise a prophylactic administration of antibiotic in selected population (patients exposed to a tick bite in endemic regions) in which the typical signs of Lyme disease are not yet appeared; conversely, patients with current signs of Lyme disease should undergo a standard therapeutic course. First-line therapy should be oral tetracycline or oral penicillin/cephalosporin (in pediatric populations, beta-lactamic drugs are preferred). In severe courses, intravenous route should be preferred.SummaryThe aim of this review...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research

Related Links:

Discussion Syphilis is caused by the spirochete Treponema pallidum. It is a very old disease that despite understanding the organism and readily available treatment, still causes disease. Syphilis is transmitted sexually. According to the Centers for Disease Control, “[i]n 2018, a total of 35,063 cases of [Primary and Secondary] syphilis were reported in the United States, yielding a rate of 10.8 cases per 100,000 population …. This rate represents a 14.9% increase compared with 2017 (9.4 cases per 100,000 population), and a 71.4% increase compared with 2014 (6.3 cases per 100,000 population).” The incre...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Abstract Sinogastromyzon sichangensis is a hillstream loach endemic to the upper Yangtze River, China. It is unclear whether this fish lives in a very restricted area or may be dispersed over a long distance. In the present study spatial connectivity of populations of S. sichangensis was investigated based on 343 individuals collected from 12 sites of Chishui River and employing 22 microsatellite loci. The results of genetic diversity analysis showed that observed heterozygosity (HO) and polymorphism information content (PIC) ranged from 0.5653 to 0.6999 and 0.8513 to 0.8819, respectively. Population structure ana...
Source: Zoological Science - Category: Zoology Authors: Tags: Zoolog Sci Source Type: research
Authors: Miserocchi E, Giuffrè C, Modorati GM, Cimaz R Abstract Italy was the first European country to be affected by the SARS-CoV-2 pandemic. In this scenario, we had to face a new clinical approach in our Pediatric Rheumatology Unit for the management of patients affected by juvenile idiopathic arthritis (JIA)-associated uveitis. During the lockdown (phase 1), the weekly outpatient clinic was discontinued and telephone consultations were set up. A toll-free telephone number was instituted for emergencies. None of our children with JIA-associated uveitis was advised to stop the ongoing immunosuppressant sy...
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Abstract Fatigue associated with arthritis is highly prevalent and interferes with patients' daily routines. An interdisciplinary research team developed the Tablet-based Cognitive Behavioral Intervention (Tab-CBI) for older adults with arthritis fatigue. The goal of the Tab-CBI is to alleviate fatigue by promoting a simple walking activity. The Tab-CBI application used off-the-shelf technologies and was implemented on a mini-tablet computer. The four key components of Tab-CBI are: (a) multimedia cognitive-behavioral therapy (CBT)-based educational modules; (b) videoconferencing communication; (c) individualized g...
Source: Journal of Gerontological Nursing - Category: Nursing Authors: Tags: J Gerontol Nurs Source Type: research
Publication date: Available online 25 September 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Maria N. Saracho Bottero, Lorenza Beati, José M. Venzal, Leonor Guardia, Carolina S. Thompson, Atilio J. Mangold, Alberto A. Guglielmone, Santiago Nava
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 25 September 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Kristyna Hrazdilova, Paulina Maria Lesiczka, Jan BardoĊˆ, Šárka Vyroubalová, Bronislav Simek, Ludek Zurek, David Modry
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 25 September 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Shahid Karim, Deepak Kumar, Steve Adamson, Joshua R. Ennen, Carl P. Qualls, José M.C. Ribeiro
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 25 September 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Ulisses A. Natividade, Angelita P. Pimenta, Rodolfo S.M. Cezar, Marcos H. Pereira, Nelder F. Gontijo, Mauricio R.V. Sant’Anna, Grasielle D. Pessoa, Leonardo B. Koerich, Ricardo N. Araujo
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
ConclusionThis study of the clinical spectrum of LD in Canadian children underlines the need for preventive measures to protect children in Canada from emerging LD, and the need for health care provider awareness.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
This study presented examples of base-calling DNA sequencing electropherograms routinely generated in a clinical diagnostic laboratory on DNA extracts of human blood specimens and ticks collected from human skin bites and from the environment. Since some of the tick samples tested were collected in Ireland, borrelial species or strains not known to exist in the United States were also detected by analysis of this 16S rRNA “core genome”. We recommend that hospital laboratories located in Lyme disease endemic areas begin to use a “core genome” sequencing test to routinely diagnose spir...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
More News: Arthritis | Brain | Children | Endemics | Infectious Diseases | Laboratory Medicine | Lyme Disease | Neurology | Pediatrics | Penicillin | Rheumatology | Skin | Tetracycline | Tickborne Diseases