Regulation of microRNAs by phytochemicals: a promising strategy for cancer chemoprevention.

Regulation of microRNAs by phytochemicals: a promising strategy for cancer chemoprevention. Curr Cancer Drug Targets. 2017 Jun 23;: Authors: Babashah S, Bakhshinejad B, Birgani MT, Pakravan K, Cho WC Abstract A growing body of evidence suggests that phytochemicals are potentially able to affect a variety of cellular processes, including proliferation, apoptosis, cell-cycle control, angiogenesis, inflammation, and DNA repair. Phytochemicals typically play pleiotropic regulatory roles in cancer cells. Chemoprevention using these natural agents has emerged as a helpful strategy to manage a variety of malignancies. With regard to cancer-associated chemopreventive mechanisms, phytochemicals can act by modulating microRNAs (miRNAs) and their target genes. This review aims to present an overview of recent findings on the effects of a number of well-characterized bioactive phytochemicals on miRNA regulation in different cancer types. The potential use of these phytochemicals for the chemoprevention and treatment of cancer is also discussed. PMID: 28669335 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research