The Structural Bioinformatics analysis of Biophenolic Lignan-Estrogen Receptor interaction.

CONCLUSION: Among the studied lignans, matairesinol showed the least binding energy as well as the most similar hydrophobic interactions to tamoxifen suggesting that matairesinol can display more efficacious biological activity to inhibit ER in comparison with pinoresinol, lariciresinol and secoisolariciresinol. Thus, our results introduce matairesinol as a potentially effective anti-ER drug. PMID: 28669348 [PubMed - as supplied by publisher]
Source: Current Cancer Drug Targets - Category: Cancer & Oncology Authors: Tags: Curr Cancer Drug Targets Source Type: research