Phase I dose escalation study of concurrent palliative radiation therapy with sorafenib in three anatomical cohorts (Thorax, Abdomen, Pelvis): The TAP study.

CONCLUSIONS: The MTD of sorafenib when used with 30Gy in 10 fractions was not established due to sorafenib-related systemic toxicity. Severe radiotherapy-related toxicities were also observed. These events suggest this concurrent combination does not warrant further study. PMID: 28668472 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research

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Although we report an increased rate of grade (G) 2 or greater radiation dermatitis (RD), predominantly driven by G2 toxicity, we do not describe a doubling in the overall rate of RD seen in patients with breast cancer undergoing adjuvant proton pencil-beam scanning (PBT). We advise counseling patients of the potential for increased dermatologic toxicity, though this should not affect modality selection, considering a very low number of patients experienced G3 to G4 RD.1Although it is notable that this increased toxicity occurs in the absence of bolus, we do not conclude that PBT should be used in lieu of photon radiation ...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
ConclusionsPRDR radiation therapy with capecitabine were well tolerated and effective method for treating patients with recurrent breast cancer. Prospective studies are necessary to compare side effects and efficacy with conventional dose rate re-irradiation, as well as, to evaluate the potential role for capecitabine in the recurrent setting.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsImmunosuppression resulted in clinical remission of each irAE, highlighting the importance of vigilance for autoimmune complications in patients treated with checkpoint inhibition, even after immunotherapy cessation.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsThese results suggest possible association of these efflux transporters with dermal inflammatory mediators, and such association could be observed in the dermatitis skin.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
Malassezia yeast plays a role in the pathogenesis of chronic dermatitis, especially in apocrine areas, by polarizing the local immunologic background to a Th2/Th17 state through aryl hydrocarbon receptor (AhR)-dependent pathways. Extra-mammary Paget ’s disease (EMPD) is an adenocarcinoma of apocrine origin and, except for cases associated with Malassezia yeast and their metabolites, the lesions typically develop in areas not exposed to environmental material. The purpose of this study was to investigate 1) the immunomodulatory effects of Mala ssezia metabolites on normal human keratinocytes (NHKCs), focusing on inter...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research
No abstract available
Source: Cancer Nursing - Category: Nursing Tags: DEPARTMENTS: Guest Editorial Source Type: research
We report the development of hidradenitis suppurativa (HS) in a patient after initiation of treatment with sorafenib. To our knowledge, sorafenib-induced HS in the axillary and inguinal skin folds has not been previously reported. A 33-year-old male on sorafenib for papillary thyroid cancer presented for evaluation of “boils” that began when he initiated chemotherapy 5 years prior and had continued to progress.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
CONCLUSION: StrataXRT® is effective for preventing, and delaying the development of grade 2 and 3 skin toxicity. TRIAL REGISTRATION: ACTRN12616000511437. PMID: 31445838 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Radiation dermatitis (RD) remains one of the most common side effects affecting patients receiving radiotherapy [1,2]. Numerous prophylactic and management interventions are available for RD including; (i) topical preparations (steroidal and non-steroidal), (ii) dressings, (iii) systemic treatments (amifostine, oral hydrolytic enzymes, pentoxifylline, and zinc supplements), and (iv) hygiene practice recommendations [3 –5]. Systematic reviews on prevention and management of RD found no evidence indicating a difference between topical pharmacological treatment and non-pharmacological topical treatment in patients under...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
ntilde;as R Abstract The pentapeptides methionine-enkephalin and leucine-enkephalin belong to the opioid family of peptides, and the non-opiate peptide adrenocorticotropin hormone (ACTH) to the melanocortin peptide family. Enkephalins/ACTH are derived from pro-enkephalin, pro-dynorphin or pro-opiomelanocortin precursors and, via opioid and melanocortin receptors, are responsible for many biological activities. Enkephalins exhibit the highest affinity for the δ receptor, followed by the μ and κ receptors, whereas ACTH binds to the five subtypes of melanocortin receptor, and is the only member of the ...
Source: Vitamins and Hormones - Category: Endocrinology Authors: Tags: Vitam Horm Source Type: research
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