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Thinking Machines: From Magic to Normal

“Technology made large populations possible; large populations now make technology indispensable.”                – Joseph Krutch (Writer)Since the 19th century, we have undergone several stages of machine revolutions.The first stage was mechanisation. The advent of modern production methods eased and sped up manufacturing, massively increasing output and ushering in the Industrial Revolution.The late 60s brought the age of the working computer. In 1967, an IBM infomercial, ‘The Paperwork Explosion’, predicted a dystopian future where unstoppable progress had created so much paperwork that it threatened humanity’s very existence, a development that could only be reversed with IBM’s advanced business machines. “They take care of the paperwork so you don’t ha ve to,” concluded the ad, with the cast adding, “Machines should work. People should think.”The current age of machine revolution is now celebrating a 20-year anniversary – in 1997, chess supremo Garry Kasparov was defeated by IBM’s Deep Blue, rocketing fledgling AI technology into the public eye. It was a task many deemed impossible at the time, as many more did before Google Deep Mind’s AlphaGo defeated the world number one board game Go player in January las t year, a decade ahead of expectations.As always, the most ambitious and innovative continue to stret...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news

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Abstract AimsThe comparative efficacy of Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy on Type 2 diabetes remission and the role of weight loss are unclear. The DiaRem Type 2 diabetes remission prediction score uses HbA1c, age and Type 2 diabetes medications but not Type 2 diabetes duration. The aim of this study was to compare the predictive value of the DiaRem score with the DiaBetter score that includes Type 2 diabetes duration, upon combined (complete plus partial) 2‐year post‐surgery Type 2 diabetes remission in people following RYGB and sleeve gastrectomy, and to investigate the relationship between ...
Source: Diabetic Medicine - Category: Endocrinology Authors: Tags: Research Article Source Type: research
Contributors : Maurice W de Ronde ; Perry D Moerland ; Sara-Joan Pinto-SietsmaSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensCardiovascular disease (CVD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Monocytes play a major role in the initiation, propagation, and progression of CVD. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. The aim of this study was to investigate whether diffe...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
Authors: Qin J, Lu C Abstract Kaposi's sarcoma-associated herpesvirus (KSHV), namely, human herpesvirus 8 (HHV-8), is considered as the pathogen of Kaposi's sarcoma (KS), the most frequent cancer in untreated HIV-infected individuals. Patients infected with HIV have a much higher possibility developing KS than average individual. Researchers have found that HIV, which functions as a cofactor of KS, contributes a lot to the development of KS. In this article, we will give a brief introduction of KS and KSHV and how the interaction between KSHV and HIV contributes to the development of KS. Also we will take a glance ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Ji Y, Lu H Abstract Currently, HIV infection and AIDS are still one of the most important epidemic diseases around the world. As early in the initial stage of HIV epidemic, the high incidence of ADCs including Kaposi sarcoma and non-Hodgkin's lymphoma was the substantial amount of disease burden of HIV infection and AIDS. With the increasing accessibility of HAART and improving medical care for HIV infection and AIDS, AIDS-related illness including ADCs has dramatically decreased. Meanwhile, the incidence of NADCs rises in PLWH. Compared with the general population, most of cancers are more likely to attac...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Yi Z, Yuan Z Abstract Most hepatitis C virus (HCV) infection results in persistent infection. Significant portion of chronic HCV-infected patients develop hepatocellular carcinoma (HCC). Chronic hepatitis C is also associated with extrahepatic manifestations, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes, and neurological disorders. The molecular mechanisms of how HCV infection causes liver cancer are largely unknown. HCV replication or viral proteins may perturb cellular hemostasis and induce the generation of reactive oxygen species (ROS); viral components or viral replication...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Li S, Bai L, Dong J, Sun R, Lan K Abstract Kaposi's sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-associated KS tissues by Drs. Yuan Chang and Patrick Moore, much progress has been made in the past two decades. There are four types of KS including classic KS, endemic KS, immunosuppressive therapy-related KS, and AIDS-associated KS. In addition to KS, KSHV is also involved in the development of primary effusion lymphoma (PEL) and certain types of multicentri...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSION: SSEH is a rare cause of paraplegia. Early radiological diagnosis is crucial for timely neurosurgical management and saving patient from permanent neurological deficit or a fatal outcome. PMID: 29047318 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
ConclusionsTo our knowledge, this is the first study that demonstrates the possible application of a dissolved oxygen electrode‐based microbial sensor in M. tuberculosis drug resistance testing. This study used the microbial sensor to perform DST of M. tuberculosis and shorten the time required for DST.This article is protected by copyright. All rights reserved.
Source: Journal of Applied Microbiology - Category: Microbiology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Counselling substantially increases linkage to care among HIV-positive adults identified through HBHCT and may enhance efforts to increase antiretroviral therapy coverage in sub-Saharan Africa. PMID: 29052344 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
“Technology made large populations possible; large populations now make technology indispensable.”                – Joseph Krutch (Writer)Since the 19th century, we have undergone several stages of machine revolutions.The first stage was mechanisation. The advent of modern production methods eased and sped up manufacturing, massively increasing output and ushering in the Industrial Revolution.The late 60s brought the age of the working computer. In 1967, an IBM infomercial, ‘The Paperwork Explosion’, predicted a dystopi...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
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