Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.

Eri1: a conserved enzyme at the crossroads of multiple RNA-processing pathways.
Trends Genet. 2014 Jun 11;
Authors: Thomas MF, L'Etoile ND, Ansel KM
Abstract
Eri1 is an evolutionarily conserved 3'-5' exoribonuclease that participates in 5.8S rRNA 3' end processing and turnover of replication-dependent histone mRNAs. Over the course of evolution, Eri1 has also been recruited into a variety of conserved and species-specific regulatory small RNA pathways that include endogenous small interfering (si)RNAs and miRNAs. Recent advances in Eri1 biology illustrate the importance of RNA metabolism in epigenetic gene regulation and illuminate common principles and players in RNA biogenesis and turnover. In this review, we highlight Eri1 as a member of a growing class of ribosome- and histone mRNA-associated proteins that have been recruited into divergent RNA metabolic pathways. We summarize recent advances in the understanding of Eri1 function in these pathways and discuss how Eri1 impacts gene expression and physiology in a variety of eukaryotic species. This emerging view highlights the possibility for crosstalk and coregulation of diverse cellular processes regulated by RNA.
PMID: 24929628 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - June 11, 2014 Category: Genetics & Stem Cells Authors: Thomas MF, L'Etoile ND, Ansel KM Tags: Trends Genet Source Type: research