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Older males 'reduce IVF conception rates'

Study suggests male age is a significant factor in successful births Related items fromOnMedica Men with infertility at risk of general health issues Fertility treatment explains most birth complications of older mums Women doing heavy or shift work have lower fertility First UK approval for gene editing on human embryos Obese couples take longer to achieve pregnancy
Source: OnMedica Latest News - Category: UK Health Source Type: news

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We examined relationships between maternal age (modeled flexibly to allow curvilinear shapes) and pregnancy outcomes using logistic regression. We plotted absolute predicted risks to display curves from age 20 to 50 estimated for two risk profiles: (1) population average values of all risk factors; (2) a low-risk profile without preexisting diabetes/hypertension, smoking, prior spontaneous/therapeutic abortion, diagnosed infertility, inadequate prenatal care, low income, rural residence, or obesity. Results: Risks of hypertensive disorders increased gradually until age 35, then accelerated. Risk of multiple gestations, ...
Source: Epidemiology - Category: Epidemiology Tags: Reproductive and Perinatal Source Type: research
(Natural News) According to the results of a study, women who take metformin, a common diabetes medication, could be putting their children at increased risk of being obese or overweight. More pregnant women with gestational diabetes or polycystic ovary syndrome (PCOS) are taking metformin to treat their conditions. PCOS usually causes infertility, and the condition can put...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Men and women follow the Wheat Belly lifestyle and can undergo important and sometime startling hormonal changes. Though results vary with stage of life—young adults, middle-aged, older—there are a variety of hormonal changes that women and men typically experience, some in concert, others independently. Such hormonal shifts can be powerful and part of the health-restoring menu of changes that develop with this lifestyle. They can even improve a relationship in a number of ways, both physically and emotionally, especially if we weave in some of the newer Wheat Belly/Undoctored concepts and practices such as oxy...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle estradiol estrogen hormonal hormones Inflammation low-carb oxytocin testosterone Thyroid Weight Loss Source Type: blogs
Abstract The increasing prevalence of morbid obesity in Germany is associated with an increasing number of metabolic surgical interventions. Short-term surgical and long-term metabolic complications - such as nutrient deficiencies - are the main risks of metabolic surgery and the resulting malabsorption. Obesity, especially morbid obesity, is associated with a high incidence of female infertility. One important cause of female infertility in obese women is the polycystic ovary syndrome, with 6 - 10%. Metabolic surgery significantly increases the fertility of obese women. The positive effect of obesity surgery ...
Source: Zentralblatt fur Chirurgie - Category: Surgery Authors: Tags: Zentralbl Chir Source Type: research
AbstractSTUDY QUESTIONDo obese levels of advanced glycation end products (AGEs) within the uterine cavity detrimentally alter tissue function in embryo implantation and placental development?SUMMARY ANSWERObese levels of AGEs activate inflammatory signaling (p65 NF κB) within endometrial epithelial cells and alter their function, cause endoplasmic reticulum (ER) stress in endometrial stromal cells and impair decidualization, compromise implantation of blastocyst mimics and inhibit trophoblast invasion.WHAT IS KNOWN ALREADYObese women experience a higher incidence of infertility, recurrent miscarriage and pregnancy co...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Conclusion TNF-α, LH, and Androstenedione could be considered as reliable predictors to depend on for recruiting the ideal women candidates with CCR-PCOD; to have the maximum benefits after LOD treatment option.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
CONCLUSION: TNF-α, LH, and Androstenedione could be considered as reliable predictors to depend on for recruiting the ideal women candidates with CCR-PCOD; to have the maximum benefits after LOD treatment option. PMID: 29408743 [PubMed - as supplied by publisher]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol Source Type: research
AbstractSTUDY QUESTIONWhat are the impacts of elevated testosterone (T) and an obesogenic western-style diet (WSD), either independently or together, on fertility and metabolic adaptations of pregnancy in primates?SUMMARY ANSWERTestosterone increases the time to achieve pregnancy, while a WSD reduces overall fertility, and the combination of testosterone and WSD additionally impairs glucose tolerance and causes pregnancy loss.WHAT IS KNOWN ALREADYBoth hyperandrogenemia and obesity are hallmarks of polycystic ovary syndrome, which is a leading cause of infertility among women worldwide. Female macaques receiving T and WSD b...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
AbstractSTUDY QUESTIONIs adherence to the Mediterranean diet (MedDiet) associated with better IVF performance in women attempting fertility?SUMMARY ANSWERGreater adherence to the MedDiet, defined using the validated Mediterranean diet score (MedDietScore), was associated with a higher likelihood of achieving clinical pregnancy and live birth among non-obese women
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Authors: Consalvo V, Canero A, Salsano V Abstract BACKGROUND: Obesity is a worldwide disease affecting 13% of the world's adult female population. The reasons and the fetal risk are still unclear. The effect of weight loss as a result of bariatric surgery seems to induce an improvement in fertility in obese women. The main purpose of this prospective study is to demonstrate if there is an association between bariatric surgery-induced weight loss and an improvement in the fertility of women at reproductive age. MATERIALS AND METHODS: From June 2013 to April 2016, all bariatric female patients from our institutes...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
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