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Lilly Wyburn with leukaemia faces double lung transplant

Lilly Wyburn, from Parkes in New South Wales, has endured rounds of gruelling treatments since being diagnosed with  leukaemia at the age of one.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) are myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) overlap disorders characterized by monocytosis, myelodysplasia, and a characteristic hypersensitivity to granulocyte-macrophage colony-stimulating factor (GM-CSF). Currently, there are no available disease-modifying therapies for CMML, nor are there preclinical models that fully recapitulate the unique features of CMML. Through use of immunocompromised mice with transgenic expression of human GM-CSF, interleukin-3, and stem cell factor in a NOD/SCID-IL2Rnull background (NSG...
Source: Blood - Category: Hematology Authors: Tags: Plenary Papers, Myeloid Neoplasia Source Type: research
Lung cavitary lesions are a rare finding in the nontransplant setting of a patient with acute leukemia. Among viral agents, cytomegalovirus (CMV) may cause pulmonary nodules and cavities in patients undergoing hematopoietic stem cell transplantation, but during pediatric acute lymphoblastic leukemia treatment, CMV disease is less common. Here we report the case of a boy affected by acute lymphoblastic leukemia who suffered severe cavitary CMV pneumonia during chemotherapy, and we review the current literature.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research
Authors: Oweira H, Schmidt J, Helbling D, Petrausch U, Schöb O, Mehrabi A, Giryes A, Elhadedy H, Abdel-Rahman O Abstract BACKGROUND: Population-based data on the development of second malignant neoplasms (SMNs) following the diagnosis of hepatocellular carcinoma (HCC) are uncommon. We evaluated this clinical vignette in HCC patients within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database (1973-2012) was queried using the SEER*Stat program to determine the clinico-pathological features of HCC patients with more than one year survival who developed SMNs. Standardized...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
With the proposed changes to the Affordable Care Act (ACA), 20 million Americans are at risk of losing their health care coverage. A survey, conducted by Brunswick Partners, found that “75 percent of Americans agree that the proposed changes to Medicaid in the AHCA are a bad idea. And that we should not allow 14 million Americans to become uninsured even if there is a potential to reduce Medicaid spending. These results are significant because they find majorities of Americans identifying as conservatives (55 percent), moderates (82 percent) and liberals (90 percent) are opposed to the AHCA’s Medicaid pro...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
AbstractWe aimed to estimate the burden of serious fungal infections in Egypt, currently unknown, based on the size of the populations at risk and available epidemiological data. Data were obtained from the World Health Organization (WHO), the Joint United Nations Programme on HIV/AIDS (UNAIDS), and published reports with clearcut denominators. When no data existed, risk populations were used to estimate frequencies of fungal infections, using previously described methodology. The population of Egypt in 2011 was ∼82,500,000; 31% children, and 8% women>60  years of age. Amongst about 21.8 million women aged 15&n...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Conclusions: Facial VCA procurement does not appear to adversely affect the outcomes of transplant recipients of concomitantly recovered solid organ allografts.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science-General: Outcomes Source Type: research
When Tim Conners collected his wish from the Make-A-Wish Foundation in 2012 at the age of 18, he was blind from childhood leukemia that had spread to his optic nerve and craving inspiration to transcend his disability. A football player and wrestler who’d never been an outdoorsman, he asked to meet Erik Weihenmayer, the first blind person to climb the Seven Summits, the highest mountains on seven continents. Tim’s wish came true. He had 2½ terrifying but transformative days of outdoor adventures in Colorado with Erik, who lost his sight to a degenerative eye disorder at 13. Now Tim is training to cl...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories acute lymphoblastic leukemia (ALL) Dana-Farber/Boston Children's Cancer and Blood Disorders Center stem cell transplant Source Type: news
Autologous stem cell transplantation (ASCT) is the standard of care for multiple myeloma patients eligible for high-dose therapy, lymphoma patients undergoing second-line treatments and for acute myelogenous leukaemia (AML) [1]. Immune system impairment and chemotherapies significantly increase the risk of infections, particularly pneumonia [2]. Overall, pulmonary complications, both infectious and non-infectious, occur in 40–60% of patients after stem cell transplantation [3], and are usually classified as early or late onset, depending on whether they occur within 100 days of the transplant [4]. The underlying...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Interstitial and orphan lung disease Original Articles: Research letters Source Type: research
We describe the first case of LIP in association with recognized genetic mutations in JMML.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Pneumonia is a major cause of morbidity in pts undergoing HSCT and AL therapy. Early FOB with culture, cytopath and viral ELISA testing improves survival. Early FOB at our center historically identified causative microorganism(s) in 37% of pts (68/183). We conducted an IRB approved prospective early FOB trial in 49 pts undergoing HSCT or AL therapy with respiratory symptoms and new radiographic lung infiltrates to determine the impact of the rapid PCR panel combined with culture testing. The PCR panel included Mycoplasma, Chlamydia, HSV, VZV, HHV7, RSV, hMPV, Rhino/Coronavirus, Adenovirus, Influenza A/B, Parainfluenza Type...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
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