Variation of mutant allele frequency in NRAS Q61 mutated melanomas

Somatic mutations of BRAF or NRAS activating the MAP kinase cell signaling pathway are present in 70% of cutaneous melanomas. The mutant allele frequency of BRAF V600E (M%BRAF) was recently shown to be highly het...

Source: BMC Dermatology - July 1, 2017 Category: Dermatology Authors: Zofia H élias-Rodzewicz, Elisa Funck-Brentano, Nathalie Terrones, Alain Beauchet, Ute Zimmermann, Cristi Marin, Philippe Saiag and Jean-François Emile Source Type: research