IgA Enhances IGF-1 Mitogenic Activity Via Receptor Modulation in Glomerular Mesangial Cells: Implications for IgA-Induced Nephropathy

Conclusion: These findings show that IgA enhances the IGF-1 activity in GMC via stimulation of IGF-1R gene transcription and suggest a role for IGF-1 in pathogenesis of IgAN.Kidney Blood Press Res 2017;42:391 –397
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research