Subtle molecular changes along the upper digestive tract could guide cancer therapy

(Georgetown University Medical Center) Based on a new molecular study of tissues biopsied from various parts of the upper digestive tract, researchers at Georgetown Lombardi Comprehensive Cancer Center have identified significant, if subtle, differences in gene mutations and other factors that could help in developing more tailored treatment options for cancer patients.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Authors: Lopes-Souza P, Dionello CF, Sá-Caputo DDC, Moreira-Marconi E, Frederico EHFF, Marchon RM, Bergmann A, Furness T, Bernardo-Filho M Abstract The purpose of this systematic review was to investigate the effects of whole body vibration (WBV) exercise in the management of cancer therapy-related morbidities. The PubMED and PEDro databases were used to access publications published in English about the use of whole body vibration (WBV) exercises in cancer patients until February 22nd 2017. The studies included were classified according to the level of evidence (LE) by the National Health and Medical Resear...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
Publication date: 1 January 2019Source: Materials Science and Engineering: C, Volume 94Author(s): Lijun You, Xiaocui Liu, Zhexiang Fang, Qianhui Xu, Qiqing ZhangAbstractA new folic acid (FA)-conjugated poly (lactic-co-glycolicacid) (PLGA)-polyethylene glycol (PEG) nano-noisome was prepared. The noisome was employed as a drug delivery system to load curcumin (Cur) as a model drug and fluorescent probe for cervical cancer therapy and cell imaging. The Fe3O4@PLGA-PEG@FA noisomes were prepared through facile emulsion solvent evaporation and conjugation chemistry method, possessing the properties of high rapid magnetic separati...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Authors: Mukherjee A, Waters AK, Babic I, Nurmemmedov E, Glassy MC, Kesari S, Yenugonda VM Abstract Antibody drug conjugates (ADC's) represent a promising and an efficient strategy for targeted cancer therapy. Comprised of a monoclonal antibody, a cytotoxic drug, and a linker, ADC's offer tumor selectively, reduced toxicity, and improved stability in systemic circulation. Recent approvals of two ADC's have led to a resurgence in ADC research, with more than 60 ADC's under various stages of clinical development. The therapeutic success of future ADCs is dependent on adherence to key requirements of their design and ...
Source: Human Antibodies - Category: Biochemistry Tags: Hum Antibodies Source Type: research
Conclusion: Although, the advanced cancer therapeutics have been established but the combination of different strategies is very important. The efficiency of the treatments depends on the stage of cancer and response of patients. Search for closely defined and selective molecular targets for a particular therapy is very complicated due to heterogenic nature of tumor environment, different therapeutic agents, incubation time, exposure doses and selectivity of therapy. The most promising photodynamic therapy (PDT) and multi- targeted therapies are being established but the question whether the cellular proteins that are most...
Source: Current Signal Transduction Therapy - Category: Molecular Biology Source Type: research
Publication date: December 2018Source: Biomedicine &Pharmacotherapy, Volume 108Author(s): Charlette Tiloke, Krishnan Anand, Robert M. Gengan, Anil A. ChuturgoonAbstractCancer is classified as one of the leading causes of global mortality. It has affected millions of people, often with poor prognosis. Having severe side-effects with conventional chemotherapy, alternate drugs and therapies are actively being investigated. There is a need for innovative drug discovery and design as existing cancer therapies are costly and not readily available. Ayurveda and traditional medicine have utilised natural resources such as plan...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Jason Roszik, Kari L. Ring, Khalida M. Wani, Alexander J. Lazar, Anna V. Yemelyanova, Pamela T. Soliman, Michael Frumovitz, Amir A. Jazaeri
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Nuryadi E, Sasaki Y, Hagiwara Y, Permata TBM, Sato H, Komatsu S, Yoshimoto Y, Murata K, Ando K, Kubo N, Okonogi N, Takakusagi Y, Adachi A, Iwanaga M, Tsuchida K, Tamaki T, Noda SE, Hirota Y, Shibata A, Ohno T, Tokino T, Oike T, Nakano T Abstract Radiotherapy is an essential component of cancer therapy. Despite advances in cancer genomics, the mutation signatures of radioresistant tumors have not yet been fully elucidated. To address this issue, we analyzed a unique set of clinical specimens from a uterine cervical cancer that repeatedly locally recurred after multiple rounds of radiotherapy. Exon sequencin...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
BioEssays, September 2018.
Source: BioEssays - Category: Molecular Biology Authors: Source Type: research
SummaryThe treatment of malignant tumors has considerably improved in recent years, and also the number of “long term cancer survivors” is increasing.The spectrum of anti-tumoral agents is increasing at a  fast pace and in addition to conventional therapies such as surgery, radiotherapy, and chemotherapy, new drugs with entirely new mechanisms are appearing. Side effects of old and new drugs can affect the central and peripheral nervous system, the neuromuscular junction, and muscle. These side effe cts often have to be distinguished from other causes and need neurological expertise. Although the majority ...
Source: Wiener Medizinische Wochenschrift - Category: General Medicine Source Type: research
In this study, a PEGylated iron MOF nanoparticle as a new and effective agent for Fenton cancer therapy method is reported. This stable nanoparticle, which can destroy cancer cells using the cells’ H2O2 does not have the issues such as low stability, high aggregation, and poor selectivity that have been reported for similar nanoparticles.
Source: Australian Journal of Chemistry - Category: Chemistry Authors: Source Type: research
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