Aberrant signaling and senescence associated protein degradation.

Aberrant signaling and senescence associated protein degradation.
Exp Gerontol. 2017 Jun 25;:
Authors: Ferbeyre G
Abstract
Senescent cells accumulate with age and contribute to pathologies associated to old age. The senescent program can be induced by pro-cancer stimuli or is developmentally controlled. In cells forced to senesce by expression of oncogenes or short telomeres, aberrant activation of the ERK/MAP kinase signaling pathway leads to selective protein degradation by the ubiquitin proteasome system. The proteins affected by this process control key cellular processes known to be defective in senescent cells. We discuss the evidence supporting a general role for aberrant signaling and senescence associated protein degradation for organismal aging.
PMID: 28658610 [PubMed - as supplied by publisher]

Source: Experimental Gerontology - June 25, 2017 Category: Geriatrics Authors: Ferbeyre G Tags: Exp Gerontol Source Type: research