The Exposome Paradigm in Human Health: Lessons from the Emory Exposome Summer Course

Conclusions The exposome concept was introduced in 2005, yet it remains in a quasi-primordial state. The Emory Exposome Summer Course was established to help advance the development of the exposome. Environmental health sciences is filled with untapped potential for human health discovery, and the exposome captures the excitement, the potential, and the dynamic nature of the field. One important point that arose from the course is the need for academic researchers to include members of the community in exposome research. Participants discussed the need to promote citizen science, and the ethical considerations inherent in this endeavor, during an open discussion. For example, how can we engage with our communities to better understand the environmental health problems they face? Might improved exposure assessment lead to increased stigmatization of and discrimination toward at-risk communities (Coughlin and Dawson 2014)? Although not a focus of the course, these crucial questions are being discussed by other organizations, including the National Academies. Another salient point that emerged from this course is the complexity of exposome projects that require long-term effort and considerable resources. Discussion at this meeting concluded that “staging” of projects and programs is essential. Staging involves defining measurable, incremental outcomes to assure all stakeholders that progress is being made and that the project remains worthwhile. We must agree on exp...
Source: EHP Research - Category: Environmental Health Authors: Tags: Brief Communication Source Type: research

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Publication date: Available online 24 February 2020Source: The Lancet Global HealthAuthor(s): Kaja M Abbas, Kevin van Zandvoort, Marc Brisson, Mark Jit
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Angiogenesis is the physiological process of new blood vessel formation from existing capillary vessel or posterior capillary vein. Its dysfunction could result in a number of different kinds of diseases, such as cardiovascular diseases and cancer, contributing to death and disability worldwide. Circular RNAs (circRNAs) are a class of novel identified RNA molecules that have a special covalent loop structure without a 5 ′ cap and 3’ tail, which can form novel back-splicing or skipping events from precursor mRNAs.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Review article Source Type: research
CONCLUSIONS: RABL6A is a new driver of MPNST pathogenesis that acts in part through p27-RB1 inactivation. Our results suggest RB1 targeted therapy with multiple pathway drugs may effectively treat MPNSTs. PMID: 32086342 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-extracellular matrix interactions. For instance, normal epithelial cells maintain tissue structure by adhering to each other and to the extracellular matrix. The proteins that mediate these distinct interactions are collectively called cell adhesion molecules and are divided into four major groups: cadherins, integrins, selectins, and immunoglobulins. They not only physically anchor cells, but also critically integrate signaling between the extracellular microenvironment and cells. These signals include biochemical cues, as adhesion protein...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: JBC Reviews Source Type: research
IJERPH, Vol. 17, Pages 1367: A Hierarchical Age–Period–Cohort Analysis of Breast Cancer Mortality and Disability Adjusted Life Years (1990–2015) Attributable to Modified Risk Factors among Chinese Women International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17041367 Authors: Mubarik Wang Malik Shi Wang Nawsherwan Yu Limited studies quantified the age, period, and cohort effects attributable to different risk factors on mortality rates (MRs) and disability-adjusted life years (DALYs) due to breast cancer among Chinese women. We used data from the Glo...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Are healthy habits worth cultivating? A recent study suggests healthy habits may help people tack on years of life and sidestep serious illnesses, such as diabetes and cancer. After all, if you’re going to gain an extra decade of life on this earth, you want to enjoy it! What did this research focus on? Researchers from the Harvard T.H. Chan School of Public Health looked at data from more than 73,000 women enrolled in the Nurses’ Health Study (NHS) who were followed for 34 years, and more than 38,000 men enrolled in the Health Professionals Follow-up Study (HPFS) who were followed for 28 years. In a previous s...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Exercise and Fitness Health Healthy Aging Healthy Eating Men's Health Women's Health Source Type: blogs
Advances in molecular profiling of tumor cells have increased potential of evolution of cancer cells and showcased need for early cancer diagnosis and personalized disease management
Source: Disabled World - Category: Disability Tags: Market Research Source Type: news
Conclusions: Healthcare providers now have information to advise clients with health conditions on the effectiveness of Tai Chi for overall health promotion.IMPLICATIONS FOR REHABILITATIONTai Chi is a form of safe, enjoyable, light-to-moderate aerobic physical activity for adults that is inexpensive to implement in diverse community settings.Adults with health conditions require physical activity for prevention of secondary impairments and over-all health promotion.This scoping review of meta-analyses elucidates "high" and "moderate" quality evidence of the effectiveness of Tai Chi in improving importan...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
AbstractNext-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures. Intriguingly, rapidly emerging data indicate that altered genes representing oncogenic drivers can also be found in sporadic non-malignant conditions, some of which have negligible and/or low potential for transformation to cancer. For instance, activatingKRAS mutations are discerned in endometriosis and in brain arteriovenous malformations, inactivatingTP53 tumor suppressor mutations in rheumatoid arthritis synovium, andAKT,MAPK, andAMPK pa...
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research
Conclusion: The findings of this present study may provide new clues for the roles of DEmRNAs and DEmiRNAs in the pathogenesis of OA.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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