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Trends in Research Literature Describing Dysphagia in Motor Neuron Diseases (MND): A Scoping Review

AbstractDysphagia in motor neuron diseases (MNDs) is highly complex, affecting all stages of swallowing and leading to impaired swallowing safety and efficiency. In order to explore the degree to which research is capturing the symptom of dysphagia in MND, we conducted a scoping review of the existing literature. The primary aims of this review were to identify common themes within the literature on dysphagia in MND, explore patterns and trends in research focus, and identify if any imbalances exist between the research themes related to dysphagia description and management. A comprehensive search strategy yielded 1690 unique articles for review. Following relevance screening, a total of 157 articles were included in the synthesis. Relevant data and keywords were extracted from each article and grouped into themes. Frequency estimates were calculated for each theme to identify trends across research literature. Swallowing impairment in MNDs is described in a variety of ways across current research. The most commonly reported theme wasAspiration/Penetration, mentioned in 73.2% of all included articles; a significant imbalance was identified between reports of swallowing safety and efficiency (p = 0.008). The most frequently reported theme related to dysphagia management wasEnteral Nutrition, and very few studies have reported on the efficacy ofRehabilitation/Compensatory recommendations. It is suggested that researchers and clinicians remain mindful of imbalances and...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research

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Abstract BackgroundMotor neuron diseases (MND) represent a group of disorders that evolve with inexorable muscle weakness and medical management is based on symptom control. However, deeper characterization of non‐motor symptoms in these patients have been rarely reported. MethodsThis cross‐sectional study aimed to describe non‐motor symptoms in MND and their impact on quality of life and functional status, with a focus on pain and sensory changes. Eighty patients (31 females, 55.7 ± 12.9 years old) with MND underwent a neurological examination, pain, mood, catastrophizing and psychophysics asse...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
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Source: Journal of Neurochemistry - Category: Neurology Authors: Tags: Original Article Source Type: research
A 70-year-old man who was admitted to neurointensive care with spastic tetraparesis and altered level of consciousness due to acute subdural hematoma and who had a history of left forefoot amputation presented right Babinski sign and left Brissaud reflex (video at Neurology.org). The Brissaud reflex is characterized by a contraction of the tensor fasciae latae due to stimulus over the plantar aspect of the foot, which is better visualized on the lateral aspect of the thigh.1,2 This is a useful neurologic sign in patients with suspected upper motor neuron disease and absent hallux. It was named after Édouard Brissaud...
Source: Neurology - Category: Neurology Authors: Tags: Clinical neurology examination, Intracerebral hemorrhage RESIDENT AND FELLOW SECTION Source Type: research
Conclusion : The present study demonstrated that LWDH-WE protects motor neurons against SMN deficiency-induced neurodegeneration, and it also improves the muscle strength of SMA-like mice, suggesting the potential benefits of LWDH-WE as a complementary prescription for SMN deficiency-related diseases. Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
The crisis in the health service has been created by politicians who want to privatise it – when public opinion, and the evidence, point in the opposite directionLike many people, I have personal experience of the NHS. In my case, medical care, personal life and scientific life are all intertwined. I have received a large amount of high-quality NHS treatment andwould not be here today if it were not for the service.The care I have received since being diagnosed with motor neurone disease as a student in 1962 has enabled me to live my life as I want, and to contribute to major advances in our understanding of the univ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: NHS Privatisation Business Economic policy Health Society Politics Health policy Public services policy UK news Source Type: news
In this study, we suggest that oxidative stress might be partly the reason for selective apoptosis in spinal motor neurons in SMA pathology, and that oxidative stress-induced apoptosis might be the therapeutic target of SMA. PMID: 28826912 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
The aim of this study was to evaluate the motor unit number, voluntary and reflex force produced by alpha motor neuron excitability in spasticity. For this purpose, electrophysiological and dynamic measurements were taken from spasticity cases and healthy participants.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
Loss of motor units (MUs) is the primary disease process in degenerative motor neuron diseases like amyotrophic lateral sclerosis (ALS). Reinnervation can compensate for MU loss. The net result is a reduced number of MUs, and increased MU size. The assessment of the number and size of MUs will be essential to study disease progression, and to study the efficacy of treatment.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
Adult patients presenting with slowly progressive hand weakness and wasting (HWW) without signs of upper motor neuron involvement and unconvincing cervical MRI signs of disk protrusion are a diagnostic challenge. Clinical and electrophysiological follow-up is needed to reach the most probable diagnosis.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
The aim of the study is to evaluate the diagnostic value of triple stimulation technique (TST) and cortical excitability studies as markers of upper motor neuron degeneration in ALS patients and to compare the extent of electrophysiological changes in abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
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