The chick eye in vision research: An excellent model for the study of ocular disease

Publication date: Available online 28 June 2017 Source:Progress in Retinal and Eye Research Author(s): C. Ellis Wisely, Javed A. Sayed, Heather Tamez, Chris Zelinka, Mohamed H. Abdel-Rahman, Andy J. Fischer, Colleen M. Cebulla The domestic chicken, Gallus gallus, serves as an excellent model for the study of a wide range of ocular diseases and conditions. The purpose of this manuscript is to outline some anatomic, physiologic, and genetic features of this organism as a robust animal model for vision research, particularly for modeling human retinal disease. Advantages include a sequenced genome, a large eye, relative ease of handling and maintenance, and ready availability. Relevant similarities and differences to humans are highlighted for ocular structures as well as for general physiologic processes. Current research applications for various ocular diseases and conditions, including ocular imaging with spectral domain optical coherence tomography, are discussed. Several genetic and non-genetic ocular disease models are outlined, including for pathologic myopia, keratoconus, glaucoma, retinal detachment, retinal degeneration, ocular albinism, and ocular tumors. Finally, the use of stem cell technology to study the repair of damaged tissues in the chick eye is discussed. Overall, the chick model provides opportunities for high-throughput translational studies to more effectively prevent or treat blinding ocular diseases.
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research

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A child receives treatment in the northeastern district of Mymensingh, Bangladesh. Credit: Naimul Haq/IPS By External SourceGENEVA, Oct 8 2019 (IPS) A staggering 2.2 billion people already suffer from eye conditions and visual impairment today, but the global need for eye care is set to increase “dramatically”, with lack of exercise a key factor, the UN health agency said on Tuesday, unveiling its first ever report on vision across the world. While welcoming recent successes in eliminating common conditions such as trachoma in eight countries, the World Health Organization (WHO) highlighted evidence indicating ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health TerraViva United Nations Source Type: news
Wassef A Chanbour, Carole G Cherfan, Elias F Jarade, Johnny M KhouryMiddle East African Journal of Ophthalmology 2019 26(3):181-183 An implantable collamer lens® (ICL) V4c model (STAAR Surgical, Monrovia, CA, USA) was placed in the eye of a 31-year-old male patient with high myopia followed by the development of malignant glaucoma. After failing medical treatment for 5 days, a noncomplicated pars plana vitrectomy and anterior hyaloidectomy succeeded in breaking the aqueous misdirection. Sixteen months later, intraoperative miotics were purposefully withheld from the ICL surgery in the fellow eye and malignant glaucom...
Source: Middle East African Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Abstract BACKGROUND/AIMS: To determine the usefulness of peripapillary retinal vessel density (VD) measured using optical coherence tomography (OCT) angiography (OCTA) in the evaluation of glaucomatous visual field damage in highly myopic eyes with primary open-angle glaucoma (POAG). METHODS: This cross-sectional observational study enrolled a total of 124 myopic POAG eyes consisting of 40 eyes showing a segmentation error (SE) in OCT scans and 84 eyes without an SE. The peripapillary retinal VD, circumpapillary retinal nerve fibre layer thickness (RNFLT) and visual field sensitivity loss (VFSL) were assessed...
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
sumoto Anthocyanin (AC) is widely used as supplement of eye health in Europe and in East Asia. In this review, I describe AC effects to clarify the mechanism is important in order to understand the effects of AC on vision health. The bioavailability of AC is quite low but, reported as intact form and many kinds of metabolite. And AC passes through the blood-aqueous fluid barrier and blood-retinal barrier. In vitro study, AC had a relaxing effect on ciliary muscle which is important to treat both myopia and glaucoma. And AC stimulate the regeneration of rhodopsin in frog rod outer segment. Furthermore, AC could inhibit...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
To investigate the natural clinical course and the risk factors of visual field (VF) progression in untreated normal-tension glaucoma (NTG) with myopia with a minimum three-year follow-up.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
Purpose: The aim of this study was to compare the diagnostic power of optic nerve head and posterior scleral configuration parameters obtained with the swept-source optical coherence tomography (SSOCT) on myopic normal-tension glaucoma (NTG). Materials and Methods: A total of 203 eyes of 203 participants with myopia diagnosed at Seoul Saint Mary’s Hospital between September 2016 and February 2018 were divided into myopic NTG group (n=113) and nonglaucomatous myopia group (n=90). Established optic nerve head (ONH) parameters such as disc torsion, horizontal tilt, and vertical tilt, and novel parameters representi...
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research
It’s no secret that air pollution isn’t good for your health. In particular, exposure to the byproducts of burning the fuel that powers most of our motor vehicles has been linked to higher risk of lung cancer, respiratory infections, stroke and heart disease, as well as an increased risk of death from these conditions. A new study now adds another worrisome pollution-related risk: eye disease. Dr. Suh-Hang Hank Juo, from the center for myopia and eye disease at China Medical University in Taiwan, and his colleagues documented for the first time in a large population that exposure to two common air pollutants&md...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health macular degeneration Pollution Source Type: news
Publication date: Available online 11 August 2019Source: Progress in Retinal and Eye ResearchAuthor(s): Craig Boote, Ian A. Sigal, Rafael Grytz, Yi Hua, Thao D. Nguyen, Michael J.A. GirardAbstractAs the eye's main load-bearing connective tissue, the sclera is centrally important to vision. In addition to cooperatively maintaining refractive status with the cornea, the sclera must also provide stable mechanical support to vulnerable internal ocular structures such as the retina and optic nerve head. Moreover, it must achieve this under complex, dynamic loading conditions imposed by eye movements and fluid pressures. Recent ...
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
Abstract Minimally invasive glaucoma surgery (MIGS) implants, such as XEN® gel stent are additional procedures in glaucoma treatment, which were designed to reduce the postoperative risk of severe hypotony and further complications. Until now the contraindications for every implant have not yet been identified. This case report describes the disastrous follow-up after implantation of a XEN® gel stent in the only high myopic eye of a patient. Despite elaborate subsequent interventions massive choroidal hemorrhage occurred with loss of the remaining visual field and total loss of visual acuity. The...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
Conclusions: The present case is the first to describe the unusual presentation of pseudoexfoliation in a young individual along with presenile cataract. Simultaneous occurrence of pseudoexfoliation with cataract could be due to previous intraocular surgery, iris trauma, possible low-grade inflammation, and high myopia in a predisposed eye. The clinician should be aware that although a rare condition, pseudoexfoliation can occur in the young and may be associated with presenile cataract.
Source: Journal of Glaucoma - Category: Opthalmology Tags: Online Articles: Case Report/Small Case Series Source Type: research
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