Effects of Low-Dose Developmental Bisphenol A Exposure on Metabolic Parameters and Gene Expression in Male and Female Fischer 344 Rat Offspring

Conclusions: Developmental exposure to 0.5 μg/kg BW/d of BPA, which is 8–10 times lower than the current preliminary EFSA (European Food Safety Authority) tolerable daily intake (TDI) of 4 μg/kg BW/d and is within the range of environmentally relevant levels, was associated with sex-specific differences in the expression of genes in adipose tissue plasma triglyceride levels in males and adipocyte cell density in females when F344 rat offspring of dams exposed to BPA at 0.5 μg/kg BW/d were compared with the offspring of unexposed controls. https://doi.org/10.1289/EHP505 Received: 13 May 2016 Revised: 19 December 2016 Accepted: 20 December 2016 Published: 28 June 2017 Address correspondence to M. Lind, Uppsala University, Dept. of Medical Sciences, Section of Occupational and Environmental Medicine, S-751 85 Uppsala, Sweden. Telephone: (46) 18 611 97 45. Email: monica.lind@medsci.uu.se Supplemental Material is available online (https://doi.org/10.1289/EHP505). *These authors contributed equally to this work. †These authors have contributed equally to this work as last authors. The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the inform...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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