Two life-threatening conditions.One remarkable wish.
When Lucas St. Onge blew out the five candles on his birthday cake, he made just one wish. He didn’t ask for ninja turtles, a T-ball set or an Xbox — the only thing he wished was to be just like any other kid. “It was a gift I couldn’t give,” says his mom, Heather. On that same day, last May, he got his wish. “He got a liver, stomach, pancreas, intestine and spleen — the five organs he needed to help him become healthy and happy,” Heather says. Heather was 18 weeks pregnant when she and her husband, Anthony, learned they were about to face a myriad of medical challenges with their unborn child. To what extent remained unclear, until the day Lucas was born. An emergency surgery to repair multiple intestinal blockages left him with short bowel syndrome, or simply “short gut,” a rare condition caused by the loss of a functioning small intestine. It meant Lucas would never be able to eat or digest food. “I was told to take him home and to let him live out his days,” Heather says. “But I wasn’t willing to accept that.” Lucas was transferred to Boston Children’s Hospital for a second opinion. SCID and a bone marrow transplant Five days after arriving at Boston Children’s, the Immunology Program team diagnosed Lucas with severe combined immunodeficiency (SCID), a rare genetic condition in which a child’s immune system is so compromised that a common cold can kil...
Effect of polyvalent immunoglobulins on the cytokine cascade in monocytes from colorectal cancer patients: Basis for a new adjuvant therapy . Int J Clin Pharmacol Ther. 2017 Dec 12;: Authors: Gasser M, Lissner R, Waaga-Gasser AM PMID: 29231166 [PubMed - as supplied by publisher]
CONCLUSION: The results suggest that the combination of lapatinib plus capecitabine can improve PFS and OS in patients with HER2-positive breast cancer that has progressed on trastuzumab. However, it appears that trastuzumab emtansine provides better treatment outcomes in this context. . PMID: 29231164 [PubMed - as supplied by publisher]
Conclusion: The overall melanoma detection rate in our free Skin Cancer Screening Program is comparable to those in European public activities. The costs of free screening programs compare favorably with the prevented potential therapeutic costs of late-stage melanoma. The low response rate of screenees agreeing to be followed up limits conclusions of this study.Dermatology
This study aimed to assess the effects of ZST93 on cell proliferation and its role in the chemosensitivity to gemcitabine in human pancreatic cancer cells. The effects of ZST93 on cancer cell proliferation, cell cycle distribution, apoptosis and autophagy were evaluated in various human pancreatic cancer cell lines, and the anti‐tumor effects of ZST93 alone and in combination with gemcitabine were identified in a xenograft mouse model. The results showed that ZST93 could inhibit the proliferation of pancreatic cancer cells and arrest cell cycle at G0/G1 phase by regulating the expression of Cyclin D1 and Cyclin A2. Moreo...
Date: Tuesday, 02 06, 2018; Speaker: Karl Koehler, Ph.D., Assistant Professor, Indiana Univ. School Of Med, Dept. of Otolaryngology-Head and Neck Sur; 40; 1201/1203
Date: Tuesday, 04 03, 2018; Speaker: Paul Bieniasz, Rockefeller University; Gordon Carmichael, University of Connecticut; Mariano Garcia-Blanco, University of Texas; Eva Gottwein, Northwestern University; Wei-Shau Hu, National Cancer Institute; Jianming Hu, Pennsylvania State University; Rozanne Sandri-Goldin, University of California, Irvine; Building: Building 45 (Natcher Building); E1/E2
Date: Monday, 04 09, 2018; Speaker: Bruno Amati, European Institute of Oncology; Jay Bradner, Novartis; Michael Cole, Dartmouth College; Chi Van Dang, Ludwig Institute for Cancer Research; Martin Eilers, University of Wurzburg; Robert Eisenman, Fred Hutch Cancer Research Center; Gerard Evan, Cambridge University; Dean Felsher, Stanford University; Carla Grandori, Cure First; Ross Hannon, John Curtin School of Medical Research; Marie Arsenian Henriksson, Karolinska Institutet; Laurence Hurley, University of Arizona; Raghu Kalluri, MD Anderson Cancer Center; Angela Koehler, Massachusetts Institute of Technology; Linda Penn, ...
This study is the first to detail intracortical ES of the injured CST. We hypothesize that cortical ES will promote CST collateralization and regeneration, prevent dieback, and improve recovery in an SCI rat model. The CST was transected at the the fourth cervical level in adult female Lewis rats trained in a stairwell grasping task. Animal groups included (a) ES333 (n = 14; 333 Hz, biphasic pulse for 0.2‐ms duration every 500 ms, 30 pulses per train); (b) ES20 (n = 14; 20 Hz, biphasic pulse for 0.2‐ms duration every 1 s, 60 pulses per train); (c) SCI only (n = 10...
CANCER symptoms affect men more than women, but spotting them early could help survival rates. Signs of the disease include diarrhoea, weight loss and back pain.
Find out what there is to know regarding the diagnosis of lupus nephritis and the available and emerging treatment strategies.Nephrology Dialysis Transplantation
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