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SIGN Apps for iPhone and iPad http://itunes.com/apps/signguidelines, https://play.google.com/store/apps/details?id=com.rootcreative.sign The SIGN app has recently been updated and now contains quick reference guides (QRGs) for:SIGN 136 Management of chronic pain SIGN 135 Management of epithelial ovarian cancer SIGN 134 Treatment of primary breast cancer SIGN 133 Management of hepatitis C The SIGN app has also had a complete re-design and now features:Optimisation for the latest operating systems Re-designed for improved legibility Send pdf button feature Split screen feature (ipad) Prevention of stroke in patients with atrial fibrillation: a guide for primary care http://www.sign.ac.uk/pdf/AF_publication.pdf This guide summarises the current evidence available to support the management of atrial fibrillation in primary care. The guide was developed by Healthcare Improvement Scotland by collating existing recent advice and guidance, including evidence-based guidelines and consensus recommendations for practice...
Source: Evidence-Based Nursing - Category: Nursing Tags: Liver disease, General practice / family medicine, Hepatitis and other GI infections, Drugs: cardiovascular system, Pain (neurology), Stroke, Diet, Pregnancy, Reproductive medicine, Breast cancer, Gynecological cancer, Lung cancer (oncology), Radiotherapy Source Type: research

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AbstractAimWe designed a prospective randomized study to assess the outcome of Colorado microdissection needle in comparison with conventional surgical blade for performing neck dissections.Materials and MethodsSixty patients who underwent neck dissection for oral cancers were randomly allocated into two groups. The outcome measurements were in terms of cosmetic outcome of neck scar, intraoperative blood loss, over all operative time, and postoperative neck drain assessment.ResultsThe use of microdissection needle in performing skin incision and neck dissection eliminates the need for local anesthetic with vasoconstrictor ...
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
ConclusionChlorhexidine diacetate-impregnated polyglactin sutures showed reduced erythema, pain and trismus in healthy patients undergoing surgical removal of third molar.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
CONCLUSION: Propofol ameliorates NP and neuroinflammation of rats by up-regulating PPAR γ expression to block the Wnt/β-catenin pathway. PMID: 32985377 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Conclusions/interpretationWhen included in the standard treatment for type 2 diabetes, dulaglutide significantly reduces LFC and improves GGT levels in participants with NAFLD. There were non-significant reductions in PFC, liver stiffness, serum AST and serum ALT levels. Dulaglutide could be considered for the early treatment of NAFLD in patients with type 2 diabetes.Trial registrationClinicalTrials.gov NCT03590626FundingThe current study was supported by an investigator-initiated study grant from Medanta –The Medicity’s departmental research fund and a grant from the Endocrine and Diabetes Foundation (EDF), In...
Source: Diabetologia - Category: Endocrinology Source Type: research
This study aims to investigate the efficacy and mechanism of action of TG-C in a rat model of OA. Using the monosodium-iodoacetate (MIA) model of OA, we examined whether TG-C could improve OA symptoms and cartilage structure in rats. Our results showed that TG-C provided pain relief a nd cartilage structural improvement in the MIA OA model over 56 days. In parallel with these long-term effects, cytokine profiles obtained on day 4 revealed increased expression of interleukin-10 (IL-10), an anti-inflammatory cytokine, in the synovial lavage fluid. Moreover, the increased levels of TGF-β1 and IL-10 caused by TG-C in...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: An environmental and community health approach, such as PEHis, in CCS long-term programs promoting the creation of healthier environments and lifestyles contributes to improving their HRQoL and secondarily other chronic diseases. PMID: 32980005 [PubMed - in process]
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
CONCLUSIONS: Exposure to elevated solar UVR levels is common among outdoor workers in Alberta. The study findings can help inform future monitoring studies and exposure reduction initiatives aimed at protecting workers. PMID: 32980002 [PubMed - in process]
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
Abstract Chemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the 'epitranscriptome', with 6-methyladenosine (m6A), 5-methylcytidine (m5C), pseudouridine and N1-methyladenosine (m1A) the most extensively investigated. Although we are just beginning to elucidate the roles of these modifications in cellular functions, there is already evidence for thei...
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
DISCUSSION: Associations between PM10 and PTB in Mexico City varied over time and across levels of PM10. Our findings of negative associations in the second and third trimesters, which are contrary to the hypothesized relationship between PM10 and PTB, may be due to a number of factors, including live birth bias and the exposure period evaluated. Differences in results for the periods evaluated suggest that PM10 from shorter exposure windows may play a more proximal role in initiating preterm labor. PMID: 32979989 [PubMed - in process]
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
DISCUSSION: Both chronic and acute ambient temperature were associated with odds of stillbirth in this low-risk population, similar to our prior nationwide findings. Future increases in temperature extremes are likely and the observed risk in a low-risk population suggests this association merits attention. PMID: 32980027 [PubMed - in process]
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research
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