Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases.

Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases.
Exp Gerontol. 2017 Jun 23;:
Authors: Coelho-Lima J, Spyridopoulos I
Abstract
Prevalence of age-associated cardiovascular diseases (CVD) has dramatically increased as a result of improvements in life expectancy. Chronic inflammation is a shared pathophysiological feature of age-associated CVDs, indicating a role for the immune system in the onset and development of CVDs. Indeed, ageing elicits profound changes in both the cardiovascular and immune system, especially in the T cell compartment. Although such changes have been well described at the cellular level, the molecular mechanisms underlying immune-mediated cardiovascular ageing remain largely unexplored. Non-coding RNAs (ncRNAs) comprise a heterogeneous family of RNA transcripts that regulate gene expression at the epigenetic, transcriptional, post-transcriptional, and post-translational levels. Non-coding RNAs have recently emerged as master modulators of T cell immunity. In this review, the state-of-the-art knowledge on ncRNA regulatory effects over T cell differentiation, function, and ageing in the context of age-associated CVDs, such as atherosclerosis, acute coronary syndromes, and heart failure, is discussed.
PMID: 28652179 [PubMed - as supplied by publisher]

Source: Experimental Gerontology - June 23, 2017 Category: Geriatrics Authors: Coelho-Lima J, Spyridopoulos I Tags: Exp Gerontol Source Type: research