'Painless' flu vaccine skin patch shows promise

Conclusion Further testing in larger trials needs to be done to be sure these initial results hold true and that the vaccine patch is safe and effective. This is the first time these flu microneedle patches have been tested on humans, and the study was relatively small, with only 100 participants. But if the results are confirmed, this new method of delivering the flu vaccination could make a big difference. The patches could have several main advantages over traditional injections: they may be preferred by people who dislike needles and avoid vaccination because of the fear of pain it may be quicker and easier to administer the vaccine yourself, than to make an appointment to have an injection the patches don't leave dangerous "sharps" waste that has to be carefully disposed of they don't have to be kept refrigerated, making it easier to store and distribute vaccines While the idea of a "no injection" vaccine sounds great if you don't like injections, they may have a much bigger impact in parts of the world where it's difficult to reach and administer vaccines with a continuous cold chain, and where health care staff are in short supply. This study is a good example of animal research that has successfully progressed through to human testing. Seven years ago the journal Nature Medicine published promising results of this flu vaccine patch tested in mice, which we discussed at the time. Now it looks as if this has the potential to become one of ...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Medication Swine flu Source Type: news

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Publication date: Available online 19 February 2020Source: Research in Veterinary ScienceAuthor(s): Ying-Feng Sun, Xuan Jiang, Ao Zhang, Ji-Fei Ma, Xiao-Xue Yu, Liu-An Li, Hai YuAbstractModified-live virus (MLV) vaccines derived from highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) were wildly used in China, which resulted in the emergence of MLV-like strains in pigs. Previous studies demonstrated that secondary bacterial infection could enhance HP-PRRSV infection-mediated inflammatory responses, but it is unknown whether early bacterial infection could enhance the HP-PRRSV MLV-like infectio...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
Authors: Kikutani K, Itai J, Ota K, Chosa K, Yamane Y, Shime N Abstract Bronchial artery aneurysms are a rare but potentially life-threatening complications because of the massive hemothorax or hemoptysis that occurs with ruptures. A 79-year-old woman was transferred to our hospital because of the sudden onset of back pain, syncope, and subsequent hypotension. Computed tomography showed a left bronchial artery aneurysm with bilateral hemothorax and hemomediastinum. Transcatheter bronchial artery embolization failed because of the anatomical location, and she went into cardiopulmonary arrest. Cardiopulmonary resusci...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Zakir HM, Masuda Y, Kitagawa J Abstract Transient receptor potential vanilloid 1 (TRPV1) is a polymodal receptor channel, which plays an important role in pain transduction. It is important to understand the functional expression of this channel under neuropathic pain (NP) conditions. A novel method was used to investigate the dynamics of functional expression of this channel on regenerated neurons under NP conditions following trigeminal nerve injury using a combination of a permanently charged sodium channel blocker (QX-314) and a TRPV1 agonist (capsaicin; QX-CAP). The combination was originally introduc...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
This study conducted experiments to assess (1) whether neural activity, indicated by Fos expression in an NRM that has experienced MM injury, is affected by the stress of repeated forced swim tests (FST); and (2) whether the selective serotonin reuptake inhibitor fluoxetine administered daily after an FST could affect the number of Fos-positive neurons in the NRM. Results revealed that the stress from repeated FSTs significantly increased the number of Fos-positive neurons in an NRM that had been affected by MM injury. Fluoxetine inhibited increases in the number of Fos-positive neurons in the NRM that occurred as a result...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
In conclusion, (+)-FUC-TMC-NP is promising anthrax vaccine adjuvant as an alternative to CpG.
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
In this study, we describe the titration tools elaborated to assess the titre of rVSV-ZEBOV productions.- A streamlined Median Tissue Culture Infectious Dose (TCID50) assay to determine the infectious titer of this vaccine was established.- A digital polymerase chain reaction (dPCR) assay to assess the total number of viral particles present in cell-free culture supernatants of rVSV productions was developed.- These assays are used to titre rVSV-ZEBOV samples and characterize the ratio of total particles to infectious units for monitoring process robustness and product quality attributes and can be used to titre samples ge...
Source: MethodsX - Category: Science Source Type: research
Prevalence and risk factors for development of subscapularis and biceps pathology in shoulders with degenerative rotator cuff disease: a prospective cohort evaluation. J Shoulder Elbow Surg. 2020 Mar;29(3):451-458 Authors: Mehta SK, Teefey SA, Middleton W, Steger-May K, Sefko JA, Keener JD Abstract BACKGROUND: The prevalence of subscapularis and long head of biceps (LHB) in relation to the presence and severity of posterosuperior (PS) rotator cuff disease is not known. METHODS: Subjects with asymptomatic rotator cuff tears were enrolled for this prospective longitudinal study (n = 354) and f...
Source: Hand Surgery - Category: Surgery Authors: Tags: J Shoulder Elbow Surg Source Type: research
ConclusionIn professional sports, when re-revision ACL reconstruction is indicated and the patient expects to return to competition, surgery should not be delayed. In these cases, the usefulness of Achilles tendon allograft should be taken into consideration for re-revision ACL reconstruction.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
ConclusionAlthough rare, osteoid osteoma may occur in the hallux. Even if the patient age, pain pattern, and radiographic findings do not exactly meet the classical definitions for osteoid osteoma, this tumor should always be included in the differential diagnosis list in patients presenting with foot pain.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
After recent revisional surgery for lumbosacral fusion, a 49-year-old woman presented to the emergency department with sudden-onset epigastric pain with nausea and vomiting. The patient's abdomen was soft, with mild diffuse tenderness without distention or evidence of rebound or guarding.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Vascular images Source Type: research
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