Distraction From Itch Shows Brainstem Activation Without Reduction in Experimental Itch Sensation.

Distraction From Itch Shows Brainstem Activation Without Reduction in Experimental Itch Sensation. Acta Derm Venereol. 2017 Jun 27;: Authors: Stumpf A, Pfleiderer B, Schneider G, Heuft G, Schmelz M, Phan NQ, Ständer S, Burgmer M Abstract The central processing of itch is not completely understood. This is the first study to use functional magnetic resonance imaging (fMRI) to examine the central modulation by distraction of experimentally induced itch. A total of 33 healthy volunteers were examined with fMRI. Periods of itch induction without distraction and itch with distraction by a Stroop task were counterbalanced during the scanning to examine task-specific changes in blood oxygenation level dependent-signal. The intensity of the subjects' itch sensation, desire to scratch and pain sensation were evaluated. Distraction by a Stroop task did not reduce itch intensity or urge to scratch. However, the Stroop task led to significantly higher activation of the left brainstem when it followed the "pure" itch sensation. Itch and pain seem to have similar inhibition pathways, particularly concerning brainstem activation during distraction. But as itch sensation, in contrast to pain, could not be sufficiently reduced by distraction, both entities might have different modulation systems. PMID: 28654133 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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ConclusionsSpecific ISRs varied among the biologic therapies assessed. The findings presented could be helpful when patients consider switching therapies due to ISRs.FundingEli Lilly and Company.
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
You're reading Can Mindfulness Meditation Really Reduce Pain and Suffering?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. There are many scientifically-validated claims about meditation's myriad benefits, but can it actually reduce chronic pain? One study demonstrated a significant decrease in chronic pain-related suffering from 10 weeks of mindfulness meditation. Another study found that meditation improves pain tolerance by 57%. How is this possible? To make sense of these results, it helps to know the diff...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness psychology self improvement meditation pain Source Type: blogs
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Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
CONCLUSION: We have demonstrated that OMC exhibits advanced analgesic, antipruritic and anti-inflammatory effects when compared with OG and OMP in ACD mice by regulating inflammation, chemokines, immune mediators and inhibiting the mRNA expression of TRPA1 and TRPV1. OMC has no irritation to the intact and damaged skin of rabbits. PMID: 31654757 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Sci Source Type: research
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Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
ConclusionsOverall, in this study with more than 70% of patients with moderate disease, patients reported high burden of disease and impact on QoL. This study demonstrates the importance of considering patient perspectives in treatment decisions that are critical for optimizing patient outcomes.FundingEli Lilly and Company.
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
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Source: Health News from Medical News Today - Category: Consumer Health News Tags: Irritable Bowel Syndrome Source Type: news
The objective was to determine whether changes in parathyroid hormone (PTH) levels are associated with changes in symptoms within this patient population.Study DesignProspective cohort.Setting &Participants165 adults with hyperparathyroidism secondary to kidney failure diagnosed, a range of dialysis vintages, and receiving regular hemodialysis from a US single-provider organization.ExposureChange in PTH levels over 24 weeks.Outcomes19 putative symptoms of secondary hyperparathyroidism measured up to 4 times using a self-administered questionnaire that assessed severity on a 5-level ordinal scale.Analytical ApproachLong...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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Source: American Journal of Health-System Pharmacy : AJHP - Category: Drugs & Pharmacology Authors: Tags: Am J Health Syst Pharm Source Type: research
Conditions:   Morphine;   Itch Interventions:   Drug: Morphine;   Drug: Placebo oral tablet;   Drug: Histamine;   Drug: Cowhage (Mucuna Pruriens);   Drug: Codeine;   Drug: Compound 48-80 Sponsor:   Aalborg University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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