Distraction From Itch Shows Brainstem Activation Without Reduction in Experimental Itch Sensation.
Distraction From Itch Shows Brainstem Activation Without Reduction in Experimental Itch Sensation. Acta Derm Venereol. 2017 Jun 27;: Authors: Stumpf A, Pfleiderer B, Schneider G, Heuft G, Schmelz M, Phan NQ, Ständer S, Burgmer M Abstract The central processing of itch is not completely understood. This is the first study to use functional magnetic resonance imaging (fMRI) to examine the central modulation by distraction of experimentally induced itch. A total of 33 healthy volunteers were examined with fMRI. Periods of itch induction without distraction and itch with distraction by a Stroop task were counterbalanced during the scanning to examine task-specific changes in blood oxygenation level dependent-signal. The intensity of the subjects' itch sensation, desire to scratch and pain sensation were evaluated. Distraction by a Stroop task did not reduce itch intensity or urge to scratch. However, the Stroop task led to significantly higher activation of the left brainstem when it followed the "pure" itch sensation. Itch and pain seem to have similar inhibition pathways, particularly concerning brainstem activation during distraction. But as itch sensation, in contrast to pain, could not be sufficiently reduced by distraction, both entities might have different modulation systems. PMID: 28654133 [PubMed - as supplied by publisher]
ConclusionsSpecific ISRs varied among the biologic therapies assessed. The findings presented could be helpful when patients consider switching therapies due to ISRs.FundingEli Lilly and Company.
You're reading Can Mindfulness Meditation Really Reduce Pain and Suffering?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. There are many scientifically-validated claims about meditation's myriad benefits, but can it actually reduce chronic pain? One study demonstrated a significant decrease in chronic pain-related suffering from 10 weeks of mindfulness meditation. Another study found that meditation improves pain tolerance by 57%. How is this possible? To make sense of these results, it helps to know the diff...
We describe a patient who suffered brachioradial pruritus for many years and was misdiagnosed by multiple specialists until she presented to our pain clinic. The patient had undergone invasive diagnostic testing by previous specialists but this had not led to diagnosis. After a thorough history and exam, the diagnosis of brachioradial pruritus was considered and the patient was treated with anticonvulsant medications, as these have been shown to be effective in this condition. This case is of interest to all physicians treating female patients as consideration of this diagnosis can avoid unnecessary invasive diagnostic testing.
CONCLUSION: We have demonstrated that OMC exhibits advanced analgesic, antipruritic and anti-inflammatory effects when compared with OG and OMP in ACD mice by regulating inflammation, chemokines, immune mediators and inhibiting the mRNA expression of TRPA1 and TRPV1. OMC has no irritation to the intact and damaged skin of rabbits. PMID: 31654757 [PubMed - as supplied by publisher]
CONCLUSION: We identified important similarities and differences in the clinical characteristics of adults with psoriasis and AD; these should help clinicians to prioritize and improve patient management. PMID: 31630393 [PubMed - as supplied by publisher]
ConclusionsOverall, in this study with more than 70% of patients with moderate disease, patients reported high burden of disease and impact on QoL. This study demonstrates the importance of considering patient perspectives in treatment decisions that are critical for optimizing patient outcomes.FundingEli Lilly and Company.
New research discovers that receptors in the nervous system that cause itchy skin also reside in the gut, explaining chronic IBS pain.
The objective was to determine whether changes in parathyroid hormone (PTH) levels are associated with changes in symptoms within this patient population.Study DesignProspective cohort.Setting &Participants165 adults with hyperparathyroidism secondary to kidney failure diagnosed, a range of dialysis vintages, and receiving regular hemodialysis from a US single-provider organization.ExposureChange in PTH levels over 24 weeks.Outcomes19 putative symptoms of secondary hyperparathyroidism measured up to 4 times using a self-administered questionnaire that assessed severity on a 5-level ordinal scale.Analytical ApproachLong...
CONCLUSION: A patient with HCC was successfully treated with pembrolizumab after experiencing adverse effects with nivolumab. PMID: 31612928 [PubMed - in process]
Conditions: Morphine; Itch Interventions: Drug: Morphine; Drug: Placebo oral tablet; Drug: Histamine; Drug: Cowhage (Mucuna Pruriens); Drug: Codeine; Drug: Compound 48-80 Sponsor: Aalborg University Not yet recruiting