Author video abstract: Fritz et al. A Classification System to Guide Physical Therapy Management in Huntington Disease: A Case Series

No description available
Source: Journal of Neurologic Physical Therapy - Video - Category: Physiotherapy Source Type: video

Related Links:

Conclusions/Implications: Our findings suggest that perceived stigma is influenced by physical, emotional, and cognitive health, which may be treated with physical therapy, emotional counseling, and cognitive rehabilitation. Application of these therapies may relieve the burden of perceived stigma; however, more research is needed in this area. (PsycInfo Database Record (c) 2020 APA, all rights reserved)
Source: Rehabilitation Psychology - Category: Rehabilitation Source Type: research
CONCLUSION: PACE-HD will enable determination of the feasibility of long-term physical activity interventions in people with HD. The novel TWiC design and incorporation of data linkage has potential to reduce participant burden. This design could be applied to other neurological diseases and movement disorders where recruitment and retention are challenging. PMID: 31101920 [PubMed - as supplied by publisher]
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: Phys Ther Source Type: research
Conclusion Our case is the second to describe worsened choreoathetoid movements with fluoxetine and psychostimulants in HD, and the first with melatonin. These observations are objectified by our patient’s marked improvements in movement and handwriting assessments (Figure 1).   We calculated Naranjo adverse event scores of 5, 5, and 2 for fluoxetine, lisdexamfetamine, and melatonin, respectively, based on several years of this individual’s outpatient medical records and current available literature (Table 1). Due to physiological and biochemical changes associated with HD progression, these medications co...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue Neurodegenerative Disease amphetamine antidepressant chorea dopamine Fluoxetine Huntington’s disease melatonin psychostimulant Source Type: research
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 144 Author(s): Lori Quinn, Monica Busse The role of rehabilitation interventions is increasingly considered a key component to effective management of people with Huntington disease (HD). Lifestyle factors, such as activity level and exercise, as well as specific motor training may be helpful in managing the functional sequelae of HD and possibly slowing disease progression. In this chapter, we focus on the role of rehabilitation therapy in secondary and tertiary prevention of the potentially devastating consequences of HD. We provide a brief overview of...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 144 Author(s): Carol Brown Moskowitz, Ashwini K. Rao Neurologists’ role in the care of people with advanced Huntington disease (HD) (total functional capacity <7), often limited by a lack of clinical research to support good practice, includes the following: (1) provide comprehensive health records to an interdisciplinary care staff before admission to a more intense care setting (home health services, day program, assisted living, group home, long-term skilled nursing facility, palliative care); (2) consult with and refer to rehabilitation (occ...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 144 Author(s): Anindita Deb, Samuel Frank, Claudia M. Testa Huntington disease (HD), an inherited neurodegenerative disease, results from a CAG repeat expansion creating mutant huntingtin protein and widespread neuronal damage. Motor symptoms such as chorea are often preceded by cognitive and behavioral changes. Tetrabenazine and deutetrabebenazine are the two drugs approved by the Federal Food and Drug Administrationfor HD symptoms, is an effective therapy for chorea. However, there is still a large need for other symptomatic therapies impacting functio...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Discussion: These cases provide proof-of-principle to support use of treatment-based classifications for physical therapy management in individuals with HD. Traditional classification of early-, mid-, and late-stage disease progression may not reflect patients' true capabilities; those with late-stage HD may be as responsive to interventions as those at an earlier disease stage. Video Abstract available for additional insights from the authors (see Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A172 ).
Source: Journal of Neurologic Physical Therapy - Category: Physiotherapy Tags: Case Studies Source Type: research
DISCUSSION: These cases provide proof-of-principle to support use of treatment-based classifications for physical therapy management in individuals with HD. Traditional classification of early-, mid-, and late-stage disease progression may not reflect patients' true capabilities; those with late-stage HD may be as responsive to interventions as those at an earlier disease stage.Video Abstract available for additional insights from the authors (see Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A172). PMID: 28628549 [PubMed - in process]
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: J Neurol Phys Ther Source Type: research
Conclusions: An important consideration in promoting translation of clinical research into practice is the ability to convey the detailed components of how the intervention was delivered to facilitate replication if the results are favorable. This report presents an illustrative example of a physical activity intervention, including the development and the training required to deliver it. This approach has the potential to facilitate reproducibility, evidence synthesis, and implementation in clinical practice. Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A122 ).
Source: Journal of Neurologic Physical Therapy - Category: Physiotherapy Tags: Research Articles Source Type: research
Introduction Huntington disease (HD) is a rare neurological disease affecting 2.71 persons for every 100,000 persons worldwide1 that leads to progressive behavioral, cognitive, and motor decline. This autosomal dominant disorder is caused by an expansion of the cytosine-adenine-guanine (CAG) repeat, which codes for the huntingtin protein2. The huntingtin protein is expressed ubiquitously and its function remains unknown, but is thought to play a role in transcription regulation3. Onset of clinical manifestations typically occurs between ages 30 and 503. CAG repeat length may explain approximately 50–70% of the varian...
Source: PLOS Currents Huntington Disease - Category: Neurology Authors: Source Type: research
More News: Brain | Huntington's Disease | Neurology | Physical Therapy | Physiotherapy